Pharma Grade Steroids Domperidone Motilium CAS 57808-66-9
2 Inquiries
57808-66-9
Shanghai, China
25kg/Drum
2022-12-31
Dichloromethane,Linocaine hydrochloride
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Product Description
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Seller Information
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Inquiry History
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Description
Domperidone Chemical Properties Melting point 240-244°C density 1.2904 (rough estimate) refractive index 1.5400 (estimate) storage temp. Store at RT solubility DMSO: >10 mg/mL form solid pka pKa 7.90 (Uncertain) color white Water Solubility Slightly soluble in water. Merck 14,3418 Stability: Stable. Incompatible with strong oxidizing agents. 
Delivery- ≤50kg, Express delivery recommended, usually called as DDU service;
- ≤500kg,Air shipping recommended, usually called as CIF service;
- >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;
- For high value products, please select air shipping and express delivery for safety.
About us
Shandong Zhishang Chemical Co.,Ltd owned by Zhishang International Group,is a new chemical enterprise with R&D.
manufacture and sales department.
Our company mainly produce pharmaceutical raw materials and intermediate(expecially Carbohydrate derivatives series).
In recent years,we had made big breakthrough in feed additive,plant extraction,industrial chemicals line.
With our "Honest operation,Quality controlling,Clients first"theory,our company enjoy good repute both home and abroad.
The R&D center located in High-tech zone in Jinan,our production based is in Chemical park of Zhangqiu and Tai'an.Our production process strictly conform with ISO 9001 and ISO 2000 standard.Our lab and workshop also follows strictly with GMP standard.Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term and stable business relations.We have large scale liquid chemical terminal and professional chemical warehouse.
We will always adhere to expand business scope and provide the best quality products and service to the world.
About us
Shandong Zhishang Chemical Co.,Ltd owned by Zhishang International Group,is a new chemical enterprise with R&D.
manufacture and sales department.
Our company mainly produce pharmaceutical raw materials and intermediate(expecially Carbohydrate derivatives series).
In recent years,we had made big breakthrough in feed additive,plant extraction,industrial chemicals line.
With our "Honest operation,Quality controlling,Clients first"theory,our company enjoy good repute both home and abroad.
The R&D center located in High-tech zone in Jinan,our production based is in Chemical park of Zhangqiu and Tai'an.Our production process strictly conform with ISO 9001 and ISO 2000 standard.Our lab and workshop also follows strictly with GMP standard.Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term and stable business relations.We have large scale liquid chemical terminal and professional chemical warehouse.
We will always adhere to expand business scope and provide the best quality products and service to the world.
ECHEMI Editorial ReferenceDomperidone is a dopamine blocker and an antidopaminergic reagent.Target: Dopamine ReceptorDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets [1]. Domperidone is a dopamine D(2) receptor antagonist, which has been used as ant
Solid
Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. It has a role as an antiemetic and a dopaminergic antagonist. It is a member of benzimidazoles and a heteroarylpiperidine.|A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.|Domperidone is a peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.Basic Info-
Product Name:
Domperidone
Other Name:2H-Benzimidazol-2-one,5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-;5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one;Domperidone;Motilium;KW 5338;R 33812;Nauzelin;Nauzelin Ds;Mod;Peridys;Gastronorm;Euciton;Peridon;Evoxin;NSC 299589;Motillium;Motinorm costi;Nomit;Domperi 10 DT;Domcolic
CAS No.:57808-66-9
Molecular Formula:C22H24ClN5O2
InChIKeys:InChIKey=FGXWKSZFVQUSTL-UHFFFAOYSA-N
Molecular Weight:425.91100
Exact Mass:425.91
EC Number:260-968-7
UNII:5587267Z69
NSC Number:759575|299589
DSSTox ID:DTXSID1045116
NCI Thesaurus Code:C454
ATC Code:A03FA03|A - Alimentary tract and metabolism
HScode:2933990090
Categories:
Characteristics-
PSA:
78.82000
XLogP3:3.29110
Appearance:Solid
Density:1.341 g/cm3
Melting Point:242.5 °C
Boiling Point:723.6±70.0 °C at 760 mmHg
Flash Point:391.4±35.7 °C
Refractive Index:1.729
Water Solubility:Slightly soluble in water.
Storage Conditions:Keep tightly closed.
PKA:7.9None
Dissociation Constants:7.9
Collision Cross Section:201.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Dichloromethane,Linocaine hydrochloride
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Location:
BUILDING 1,HISENSE INTELLIGENCE VALLEY,NO.2116,OF PHOEIX ROAD, HIGH-TECH ZONE ,JINAN CITY ,SHANDONG PROVINCE,CHINA
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Payment Terms:
D/P,L/C,D/A
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Average lead Time:
15
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2016
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
United States
Domperidone USP
25 KG Oct 10, 2024 
India
DOMPERIDONE BP/USP
30.00 KG Oct 9, 2023 Post an enquiry for this product
