Griseofulvin Chifeng
5 Inquiries
126-07-8
shanghai
20kg/drum
2022-03-31
D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceIt is white or white-like powder. Melting point is 218-224 °C. It is highly soluble in tetrachloroethane, soluble in acetone or chloroform, slightly soluble in methanol or ethanol, and very slightly soluble in water. It is odorless or almost odorless with slightly bitter taste. It is stable to heat. Crystalline SolidChEBI: An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not res
Griseofulvin appears as white to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F. (NTP, 1992)|Solid
Griseofulvin appears as white to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F. (NTP, 1992)|Griseofulvin is an oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment. It has a role as an antibacterial agent and a Penicillium metabolite. It is an organochlorine compound, a member of 1-benzofurans, an oxaspiro compound, an antibiotic antifungal drug and a benzofuran antifungal drug.|An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.|Griseofulvin is a Tubulin Inhibiting Agent. The physiologic effect of griseofulvin is by means of Decreased Mitosis, and Microtubule Inhibition.|Griseofulvin is a fungistatic agent used to treat superficial fungal skin infections such as tinea capitis and pedis. Griseofulvin therapy can cause transient mild-to-moderate serum aminotransferase elevations and has very rarely been linked to clinically apparent acute drug induced liver injury.|Griseofulvin is an antifungal agent derived from the mold Penicillium griseofulvum that is used to treat fungal infections of the skin and nails. Griseofulvin binds to tubulin, disrupting microtubule function and inhibiting mitosis.|An antifungal agent used in the treatment of TINEA infections.
Griseofulvin (126-07-8) is an antifungal antimitotic agent. Induces apoptosis of human germ cell tumor cells via disruption of connexin 43/tubulin association concomitant with enhanced translocation of connexin 43 from the cytoplasm to the nucleus.1Inhibits the growth of adrenocortical cancer cellsin vitro.2 Griseofulvin inhibits centrosome clustering, induces spindle multipolarity, mitotic arrest and cell death in multiple tumor cell lines but not in diploid fibroblasts and keratinocytes with normal centrosome content.3
Crystalline SolidBasic Info-
Product Name:
(+)-Griseofulvin
Other Name:7-Chloro-2,4,6-trimethoxy-6-methyl-, (1S-trans)-Spiro(benzofuran-2(3H),1-(2)cyclohexene)-3,4-dione;Grisovi;Griseofulvin, (2S)-trans-7-Chloro-2μ,4,6-trimethoxy-6μ-methylspiro(benzofuran-2[3H],1μ-[2]cyclohexene)-3,4μ-dione;7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;Grisact;(+)-Griseofulvin,97%;GRISEOFULVIN(RG);Griseofulvin (200 mg)
CAS No.:126-07-8
Molecular Formula:C17H17ClO6
InChIKeys:DDUHZTYCFQRHIY-RBHXEPJQSA-N
Molecular Weight:352.77
Exact Mass:352.77
BRN:95226
EC Number:204-767-4
UNII:32HRV3E3D5
NSC Number:755822
DSSTox ID:DTXSID8020674
NCI Thesaurus Code:C65819
Color/Form:White to yellow-white
ATC Code:D - Dermatologicals
HScode:29419090
Categories:
Characteristics-
λmax:
321nm(CHCl3)(lit.)
PSA:71.1
XLogP3:2.2
Appearance:White to yellow-white Powder
Density:1.2579 (rough estimate)
Melting Point:218-220 °C(lit.)
Boiling Point:469.04°C (rough estimate)
Flash Point:228.0±29.1 °C
Refractive Index:1.4429 (estimate)
Water Solubility:practically insoluble
Storage Conditions:−20°C
Vapor Pressure:3.11E-11mmHg at 25°C
Toxicity:Griseofulvin has a relatively low toxicity to warm-blooded animals; intraperitoneal injection of both sexes of Waster rats found that they could both withstand a dosage of per 100ml/kg (some damage effects on the seminal vesicles and the intestinal epithelium were observed). Although intravenous injection can cause the temporary inhibition of cells mitosis (especially bone marrow some cells), the rates were almost unaffected under normal conditions. Moreover, after 24 hours, the rats began to rapidly recover; its LD50 is 400ml/kg body weight. Furthermore, even a large dose of griseofulvin only has a very small toxicity to the plants. It will be slowly degraded in the body with a faster degradation rate in soil; so there are no issues about residue and environmental pollution problems. However, the property of its fast degradation also limits their application of antimicrobial activity in agriculture.
Flammability characteristics:Combustion produces toxic chloride gas
Specific rotation:354 º (c=1, dimethylform)
Odor:ODORLESS
Collision Cross Section:178.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:SUBLIMES WITHOUT DECOMP @ 210 °C
Air and Water Reactions:Insoluble in water.
Reactive Group:Ethers
Reactivity Profile:(+)-Griseofulvin is incompatible with strong oxidizing agents. .
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Skin sensitization, Category 1
Carcinogenicity, Category 2
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H317 May cause an allergic skin reaction
H351 Suspected of causing cancer
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
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Seller Information
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Business Type:
Manufactory
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Main Products:
D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP
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Location:
1613 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China.
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
7
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
11-50
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Year of Establishment:
2011
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Griseofulvin
500 KG Oct 8, 2024 
Bangladesh
Griseofulvin BP/EP
1 KG Jul 18, 2024 
India
greisofluvin
1 TON Apr 19, 2024 
Saudi Arabia
GRISEOFULVIN
1 KG Feb 23, 2024 
Belgium
Griseofulvin
8 KG Nov 20, 2023 Post an enquiry for this product
