Ropivacaine hydrochloride, Ropivacaine HCl, Naropin 99% white powder 132112-35-7 Senwayer

Ropivacaine Hydrochloride is a long-acting anesthetic drug that is used in the management of acute pain syndromes and for regional/ surgical anesthesia.

Ropivacaine HCl is chemically described as S-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate. The drug substance is a white crystalline powder, with the following structural formula:

Ropivacaine Uses

Acute pain management:

• • For acute pain management administered as an epidural continuous infusion, intermittent bolus (eg, postoperative or labor), or local infiltration.

• Surgical anesthesia:

  • For local or regional anesthesia for surgery administered as an epidural block, including cesarean section, major nerve block, or local infiltration.

Product Function

Ropivacaine is a local anaesthetic with a similar structure to bupivacaine. The drug has been approved for epidural blocks, field blocks and major nerve blocks. It can be used in surgery, during labour and for postoperative pain.

Product Side Effect

The adverse effects of ropivacaine are similar to those of bupivacaine and include hypotension, bradycardia, nausea and vomiting. There is some evidence from animal studies that ropivacaine has less central nervous system and cardiovascular toxicity than bupivacaine. Acute systemic toxicity can cause convulsions, apnoea and cardiac arrest.

Note

At high doses, ropivacaine produces surgical anaesthesia, while lower doses cause a sensory block. These effects begin within a few minutes and last for 2-6 hours when ropivacaine is used for field blocks. The onset is similar when the drug is used for lumbar epidural anaesthesia, but the duration is shorter. Ropivacaine is extensively metabolised, so it is not recommended for patients with hepatic dysfunction.