Palmitoyl pentapeptide, Palmitoyl pentapeptide-4, Matrixyl, Palmitoyl Pentapeptide-3 99% white powder 214047-00-4 Senwayer

Palmitoyl pentapeptide-4 is a matrikine used in anti-wrinkle cosmetics. It was launched in 2000 as an active ingredient for the personal care industry under the trade name Matrixyl by the French cosmetic active ingredient manufacturer Sederma SAS.

Palmitoyl Pentapeptide-4 was developed by the corporations Sederma SA and Proctor & Gamble and originally named Palmitoyl Pentapeptide-3, but later renamed to Palmitoyl Pentapeptide-4 to reflect a correction in the data on its molecular structure, according to research. It is also included in many commercial formulas under the trademark of Matrixyl.

Palmitoyl Pentapeptide-4 is a pentapeptide, synethsized chain protein created by linking five amino acid peptides. This chain creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin (FN) and glycosaminoglycans (GAG), according to research. Palmitoyl Pentapeptide-4 is a small molecule that penetrates the skin easily and is structurally similar to the precursor of collagen type I. It is thought that pentapeptides can communicate with a cell and program it to do specific things, including repair work.

Palmitoyl Pentapeptide-4 is considered to be as effective against wrinkles as retinol, but less irritating. According to SmartSkinCare.com, "One study found that Palmitoyl Pentapeptide-4 was as effective as retinol in repairing sun-damaged skin but was devoid of side-effects. Most other studies showed at least some improvement in various objective and subjective measures of wrinkles."

Independent in vitro studies (unlike most studies available on Palmitoyl Pentapeptide-4, which have been done by P&G, originators of Matrixyl) demonstrated an increase in synthesis of Collagen I by 212%, Collagen IV by 100 to 327% and Hyaluronic Acid by 267%. Collagen I is predominant among the 19 forms of collagen found in the human body; therefore increasing production of Collagen I has a very dramatic effect on rebuilding the skin. Six month in vivo studies showed mean wrinkle depth was reduced by 17%, surface area containing deep wrinkles was reduced by 68%, surface area containing moderate wrinkles was reduced by 51% and skin roughness by 16% .

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• 1. Increase overall collagen synthesis by up to 117%
• 2. Increase collagen IV synthesis by up to 327%
• 3. Increase hyaluronic synthesis by up to 267%

Deep wrinkles were reduced by half. Smaller wrinkles and fine lines sometimes faded completely away. And what's even better, every participant in the study showed noticeable improvement within two weeks. The result was fewer wrinkles and younger-looking skin.

There are very few ingredients that show more promise and greater effectiveness than Matrixyl. When combined with other peptides (see our article last week on Argireline) the results are even more effective.

The EWG gives Palmitoyl Pentapeptide-4 a zero rating based on 100% data gap. No studies were found that noted harmful side effects or safety warnings regarding its use. However, independent studies of this ingredient are rare.

For the ultimate in wrinkle-fighting, pick this peptide, which targets those pesky lines and wrinkles two ways.

Prevents dynamic wrinkles from forming: “Argireline is very specific in that it interferes with a protein receptor complex which helps cause muscle movement,” says Bae. Translation: It keeps the nerves from talking to the muscles and telling them to contract—and fewer muscle contractions result in fewer wrinkles.

Stimulates collagen production: By increasing the production of collagen, the protein responsible for firm, healthy skin, it also helps to keep fine lines and wrinkles from forming.

Helps the skin retain moisture: Argireline also optimizes collagen function, which, along with the skin-smoothing effects, improves moisture levels in the skin, says Shah. And hydrated skin is always going to look more youthful than dry skin.

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