Stavudine
3056-17-5
industrial Grade
98%
SHANGHAI
KieRay Chem
25kg/drum
2022-12-31
fine chemicals,pharmaceutical materials
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceStavudine is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.Target: HIV RT; NRTIsStavudine is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termina
2',3'-didehydro-3'-deoxythymidine appears as white crystalline solid or powder. Odorless. (NTP, 1992)|Solid
2',3'-didehydro-3'-deoxythymidine appears as white crystalline solid or powder. Odorless. (NTP, 1992)|Stavudine is a nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase It has a role as an antimetabolite, an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor and an antiviral agent. It is an organic molecular entity, a nucleoside analogue and a dihydrofuran. It derives from a thymine.|A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.|Stavudine is a Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of stavudine is as a Nucleoside Reverse Transcriptase Inhibitor.|Stavudine is a first generation nucleoside analogue and reverse transcriptase inhibitor used in combination with other agents in the therapy of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). Stavudine is an uncommon, but well established cause of clinically apparent acute and chronic liver injury.|Stavudine is a nucleoside reverse transcriptase inhibitor analog of thymidine. Stavudine has been recommended to undergo phase-out management due to its long-term, irreversible side-effects.Basic Info-
Product Name:
Stavudine
Other Name:Thymidine,2′,3′-didehydro-3′-deoxy-;Thymine,1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-;2,4(1H,3H)-Pyrimidinedione,1-[(2R,5S)-2,5-dihydro-5-(hydroxymethyl)-2-furanyl]-5-methyl-;2′-Thymidinene,3′-deoxy-;2′,3′-Didehydro-3′-deoxythymidine;d4T;3′-Deoxy-2′,3′-didehydrothymidine;BMY 27857;D 4T (nucleoside);Stavudine;Sanilvudine;Zerit;NSC 163661;Stavir;Virostav;Stag;Avostav;Staduvine;Melxicap;2′,3′-Didehydro-2′,3′-dideoxythymidine;132425-31-1;1348378-24-4
CAS No.:3056-17-5
Molecular Formula:C10H12N2O4
InChIKeys:InChIKey=XNKLLVCARDGLGL-JGVFFNPUSA-N
Molecular Weight:224.21
Exact Mass:224.21
EC Number:1308068-626-2
UNII:BO9LE4QFZF
NSC Number:759897
DSSTox ID:DTXSID1023819
NCI Thesaurus Code:C1428
Color/Form:White to off white crystalline solid|Colorless granular solid from ethanol/benzene
ATC Code:J05AF04|J - Antiinfectives for systemic use
HScode:2938901000
Categories:
Characteristics-
PSA:
78.9
XLogP3:-0.8
Appearance:2',3'-didehydro-3'-deoxythymidine appears as white crystalline solid or powder. Odorless. (NTP, 1992)
Density:1.5±0.1 g/cm3
Melting Point:165-166 °C
Flash Point:220.3±31.5 °C
Refractive Index:-46 ° (C=0.69, H2O)
Water Solubility:H2O: 5-10 g/100 mL at 21 ºC
Storage Conditions:−20°C
Vapor Pressure:9.5X10-12 mm Hg at 25 deg C /Estimated/
Toxicity:LD50 oral in rat: 4gm/kg
Specific rotation:D25 -39.4° (c = 0.701 in water); D20 -46.1° (c = 0.7 in water)
Henrys Law Constant:Henry's Law constant = 2.3X10-15 atm-cu m/mole at 25 °C /Estimated/
Experimental Properties:Hydroxyl radical reaction rate constant = 1.21X10-10 cu cm/molec-sec at 25 °C /Estimated/|Ozone reaction rate constant = 2.1X10-16 cu cm/molec-sec at 25 °C /Estimated/
Air and Water Reactions:Water soluble.
Reactive Group:Alcohols and Polyols
Reactivity Profile:2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE is sensitive to heat. Incompatible with strong oxidizing agents (NTP, 1992).
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H341 Suspected of causing genetic defects
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
fine chemicals,pharmaceutical materials
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Location:
Room 260, Building 3, No. 76 Xingqiao North Road, Xingqiao Street, Yuhang District, Hangzhou City, Zhejiang Province, China
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2020
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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