Anti-Cancer Pirespa Powder CAS 53179-13-8 Pirfenidone
HALAL ISO FDA
53179-13-8
Pharmaceutical Grade
0%
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Boil Bag
2022-12-31
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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Description
Anti-cancer Pirespa Powder CAS 53179-13-8 Pirfenidone
Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II.
In September 2011, the Chinese State Food and Drug Administration provided GNI Group Ltd with new drug approval of pirfenidone in China, and later manufacture approval in 2013
Pirfenidone is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep within your lungs. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. Decreased lung function can make it hard for you to breathe. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen.
The cause of IPF is often unknown, but this condition is a progressive disease that can be fatal. Pirfenidone is not a cure for IPF, but this medicine may slow the progress of this disease.
Pirfenidone may also be used for purposes not listed in this medication guide.
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In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
CertificatesBasic Info-
Product Name:
Pirfenidone
Other Name:2(1H)-Pyridinone,5-methyl-1-phenyl-;5-Methyl-1-phenyl-2(1H)-pyridinone;Pirfenidone;5-Methyl-1-phenyl-2(1H)-pyridone;AMR 69;5-Methyl-1-phenyl-1H-pyridin-2-one;Deskar;Pirespa;Esbriet;RG6062;RG 6062;RG-6062;835632-50-3
CAS No.:53179-13-8
Molecular Formula:C12H11NO
InChIKeys:InChIKey=ISWRGOKTTBVCFA-UHFFFAOYSA-N
Molecular Weight:185.22200
Exact Mass:185.22
UNII:D7NLD2JX7U
NSC Number:748456
DSSTox ID:DTXSID4045183
NCI Thesaurus Code:C2635
Color/Form:White solid from hot water
ATC Code:L04AX05|L - Antineoplastic and immunomodulating agents
HScode:2933399090
Categories:
Characteristics-
PSA:
22.00000
XLogP3:1.9
Appearance:Off-White Solid
Density:1.137 g/cm3
Melting Point:96-97ºC
Boiling Point:329.1ºC at 760 mmHg
Flash Point:152.7ºC
Refractive Index:1.592
Water Solubility:DMSO: ≥10 mg/mL, soluble ;Solubule in methanol
Storage Conditions:Store at RT
Vapor Pressure:3.68X10-5 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 9.16X10-8 at 25 °C (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 5.12X10-12 cu cm/molecule-sec at 25 °C (est)|Ozone radical reaction rate constant = 5.26X10-17 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
