High Quality Anti-Tumor Raw Powder Topotecan Hydrochloride CAS 119413-54-6
GMP HALAL KOSHER ISO FDA
119413-54-6
Pharmaceutical Grade
99.9%
Foil Bag, Box, Drum
2022-12-31
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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Description
Product Name Topotecan hydrochloride CAS No. 119413-54-6 Molecular Formula C23H24ClN3O5 Molecular Weight 457.91 EINECS No. 1308068-626-2 Melting point 213-218°C Boiling point 782.9ºC at 760mmHg Flash point 427.3ºC Steam pressure 8.13E-26mmHg at 25°C PSA 104.89000 LogP 2.64880 Refractive index 1.733 Appearance White Powder Purity 99% Quality Standard Enterprise standard Storage Conditions Refrigerator Packing 1kg/foil bag;25kg/drum Shipment EMS;DHL;FedEx;TNT;UPS Delivery Time 4-7 Working Days Payment terms T/T;Western Union;Money Gram;Bitcoin Usage The best drugs for the treatment of ovarian cancer at present; Treatment of breast cancer, rectal cancer, colon cancer, acute and chronic white blood cell disease; used as anti-tumor drugs 
Topotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy.
In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The 3 clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome.
Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors.
Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.
CertificatesBasic Info-
Product Name:
Topotecan hydrochloride
Other Name:1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,hydrochloride (1:1),(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,monohydrochloride,(S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,monohydrochloride,(4S)-;SKF 104864A;NSC 609669;Topotecan hydrochloride;Hycamtin;SKFS 104864A;Nogitecan hydrochloride;Topotecan chlorohydrate;(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride;Xinze
CAS No.:119413-54-6
Molecular Formula:C23H23N3O5.ClH
InChIKeys:InChIKey=DGHHQBMTXTWTJV-BQAIUKQQSA-N
Molecular Weight:457.91
Exact Mass:421.163757
EC Number:1308068-626-2
UNII:956S425ZCY
NSC Number:759263|609699
DSSTox ID:DTXSID1045952
NCI Thesaurus Code:C2828
ATC Code:L01CE01
HScode:29420000
Categories:
Characteristics-
PSA:
103
XLogP3:2.64880
Appearance:White Crystalline Solid
Density:1.5±0.1 g/cm3
Melting Point:215 °C (decomp)
Boiling Point:782.9ºC at 760mmHg
Flash Point:427.3±32.9 °C
Refractive Index:1.734
Storage Conditions:Refrigerator
Vapor Pressure:8.13E-26mmHg at 25°C
Collision Cross Section:211.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H340 May cause genetic defects
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Country Product Purchase Quantity Date Posted Post an enquiry for this product