Olutasidenib (Synonyms: FT-2102)
1887014-12-1
Industrial Grade
99%
Dideu
25kg/Cardboard Drum
Yes
2022-12-31
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceOlutasidenib is under investigation in clinical trial NCT04013880 (ASTX727 and FT-2102 in Treating Idh1-mutated Recurrent/refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia).|Olutasidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1; IDH-1; IDH1 [NADP+] soluble) with a mutation at arginine (R) 132, IDH1(R132), with potential antineoplastic activity. Upon administration, olutasidenib specifically inhibits IDH1(R132), thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH(R132). IDH1(R132) mutations are highly expressed in certain malignancies, including gliomas; they initiate and drive cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG.Basic Info
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Product Name:
Olutasidenib
Other Name:Olutasidenib;1887014-12-1;FT-2102;UNII-0T4IMT8S5Z;Olutasidenib (FT-2102);0T4IMT8S5Z;FT2102;(S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;5-[[(1S)-1-(6-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]amino]-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile;5-[[(1S)-1-(6-chloro-2-oxo-1H-quinolin-3-yl)ethyl]amino]-1-methyl-6-oxopyridine-2-carbonitrile
CAS No.:1887014-12-1
Molecular Formula:C18H15ClN4O2
InChIKeys:NEQYWYXGTJDAKR-JTQLQIEISA-N
Molecular Weight:354.8
Exact Mass:354.0883534
UNII:0T4IMT8S5Z
NCI Thesaurus Code:C129687
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
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ISO Certificate
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REACH
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