Ramosetron hydrochloride 99% white powder 132907-72-3 Senwayer
TDS
132907-72-3
Pharmaceutical Grade
99%
shanghai
Senwayer
bag
2023-05-12
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceRamosetron hydrochloride is a member of indoles.|Ramosetron Hydrochloride is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity. Upon administration, ramosetron selectively binds to and blocks the activity of 5-HT subtype 3 (5-HT3) receptors located in the vagus nerve terminal and in the vomiting center in the central nervous system (CNS), suppressing chemotherapy-induced nausea and vomiting.
Ramosetron Hydrochloride is the only currently available drug indicated for the treatment of male patients with IBS-D in Japan. Ramosetron Hydrochloride was approved in July 1996 under a brand name of Nasea Injection 0.3 mg and in June 1998 under a brand name of Nasea OD tablets 0.1 mg for the treatment of gastrointestinal symptoms (nausea and vomiting) associated with therapy with antineoplastic drugs (e.g., cisplatin).Nasea was launched in Japan for chemotherapy-induced emesis. Nasea was prepared by a four step sequence via the Vilsmeier-type coupling of 1-methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl-benzimidazole hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and was 8670 times more potent than netoclopramide.
White Solid
ChEBI: Ramosetron hydrochloride is a member of indoles.Certificates-
TDS
Basic Info-
Product Name:
Ramosetron hydrochloride
Other Name:Methanone,(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]-,hydrochloride (1:1);(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride;(1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone hydrochloride;RAMOSETRON HYDROCHLORIDE;(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon;(r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr;(r)-monohydrochlorid;ym060
CAS No.:132907-72-3
Molecular Formula:C17H18ClN3O
InChIKeys:XIXYTCLDXQRHJO-RFVHGSKJSA-N
Molecular Weight:315.8
Exact Mass:315.1138399
UNII:9551LHD87E
DSSTox ID:DTXSID3021223
NCI Thesaurus Code:C88299
Color/Form:white to beige
Categories:
Characteristics-
Melting Point:
244-246°C
Water Solubility:H2O: 20mg/mL, clear
Toxicity:dog,LD,intravenous,> 30mg/kg (30mg/kg),SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE,Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 117, 1994.
Critical Temperature & Pressure:-20°C
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Seller Information
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Business Type:
Trader
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Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid
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Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
10 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
51-100
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Year of Establishment:
2020
Company Certificates-
Verified supplier certificate
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SGS
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