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Terfenadine

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CAS No.:

50679-08-8

Content:

99%

Packaging:

Bottle,barrel,cargo,container,etc.

Sample Available:

Yes

Price valid (until):

2026-11-24

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HANGZHOU LEAP CHEM CO., LTD.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C

Average Lead Time:

5 days

Qualification:

Main Products:

Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals

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Product Details
Seller Information

Description

Keywords

50679-08-8

Terfenadine

C32H41NO2

Quick Details

ProName:

Terfenadine

CasNo:

50679-08-8

Molecular Formula:

C32H41NO2

Appearance:

powder, or liquid

Application:

Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals

DeliveryTime:

5-7 Days

PackAge:

Bottle, barrel, cargo, container, etc.

Port:

Shanghai

Purity:

Storage:

Stored in room temperature, ventilated place

Transportation:

By air, ship, express, etc.

LimitNum:

Grade:

Industrial Grade

Superiority

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick Response

Details

LEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicals

ECHEMI Editorial Reference

Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM.IC50 value: 204 nMTarget: HERGTerfenadine normally undergoes extensive first-pass metabolism in the liver to produce an active acidic metabolite. Terfenadine is a widely used, over-the-counter drug to treat allergies.
Solid
Terfenadine is a diarylmethane.|In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.|Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways.|A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

Basic Info

Product Name:

Terfenadine

Other Name:

1-Piperidinebutanol,α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-;α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol;α-(p-tert-Butylphenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidinebutanol;Terfenadine;Teldane;Seldane;dl-Terfenadine;(±)-Terfenadine;Racemic terfenadine;Histadin;Triludan;NSC 665802;MDL 9918;Nebralin;Cyater;Allerplus;Terdin;Ternadin;Terfex;Teldanex;Histafen;Terfinax;1-(4-tert-Butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol;126588-95-2;43076-19-3

CAS No.:

50679-08-8

Molecular Formula:

C32H41NO2

InChIKeys:

InChIKey=GUGOEEXESWIERI-UHFFFAOYSA-N

Molecular Weight:

471.67

Exact Mass:

471.67

EC Number:

256-710-8

NSC Number:

758627|665802

DSSTox ID:

DTXSID2023642

NCI Thesaurus Code:

C29494

Color/Form:

White to off-white crystalline powder|Crystals from acetone

ATC Code:

R - Respiratory system

HScode:

2933399090

Categories:

Antiallergic Drugs

Characteristics

PSA:

43.7

XLogP3:

7.1

Appearance:

Solid

Density:

1.1±0.1 g/cm3

Melting Point:

146.5-148.5 °C

Boiling Point:

626.8±55.0 °C at 760 mmHg

Flash Point:

306.9±30.2 °C

Refractive Index:

1.580

Water Solubility:

H2O: 0.001 g/100 mL (30 ºC);chloroform: soluble 250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellow

Storage Conditions:

2-8°C

Vapor Pressure:

9.4X10-15 mm Hg at 25 deg C (est)

Toxicity:

LD50 orally in mice: >2000 mg/kg (Carr, Meyer)

Henrys Law Constant:

Henry's Law constant = 2.1X10-13 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa = 8.91 (tertiary nitrogen) (EST)

Collision Cross Section:

229.8 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|226.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|226.3 Å² [M+H]+

Experimental Properties:

Hydroxyl radical reaction rate constant = 1.4X10-10 cu cm/molecule-sec at 25 °C (est)

See More Terfenadine Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	H413 May cause long lasting harmful effects to aquatic life
Prevention	P273 Avoid release to the environment.
Response	none
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Terfenadine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals

Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang

Payment Terms:
TT against copy of documents,D/P,L/C

Average lead Time:
5 days

Total Annual Revenue:
Above $100 million

Year of Establishment:
2020

Company Certificates
- ISO
Company Profile
LEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.

Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction

We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
LEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.

Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction

We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
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Terfenadine

Product Details

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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