Fluocinolone acetonide 99% Dideu-5-00472 Dideu
1 Inquiries
67-73-2
Industrial Grade
99%
Dideu
25kg/Cardboard Drum
Yes
2022-12-31
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceFluocinolone Acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders.Target: Glucocorticoid ReceptorFluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold und
Fluocinolone acetonide is a fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a cyclic ketal, a glucocorticoid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid, an organic heteropentacyclic compound and a primary alpha-hydroxy ketone.|Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices. This type of device containing fluocinolone acetonide was developed by Taro Pharmaceuticals and approved by FDA in May 2016.|Fluocinolone acetonide is a Corticosteroid. The mechanism of action of fluocinolone acetonide is as a Corticosteroid Hormone Receptor Agonist.|Fluocinolone Acetonide is the acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow.|A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)Basic Info-
Product Name:
Fluocinolone 16,17-acetonide
Other Name:Pregna-1,4-diene-3,20-dione,6,9-difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6α,11β,16α)-;Pregna-1,4-diene-3,20-dione,6α,9-difluoro-11β,16α,17,21-tetrahydroxy-,cyclic 16,17-acetal with acetone;2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole,pregna-1,4-diene-3,20-dione deriv.;(6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;6α,9α-Difluoro-16α,17α-isopropylidenedioxy-Δ1-hydrocortisone;6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide;6α,9-Difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17 acetal with acetone;Fluocinolone acetonide;16α,17α-Isopropylidene-6α,9α-difluoro-1,4-pregnadiene-11β,16α,17α,21-tetrol-3,20-dione;Synalar;Fluocinolone 16,17-acetonide;6α-Fluorotriamcinolone acetonide;6α,9α-Difluoro-16α-hydroxyprednisolone 16,17-acetonide;Dermalar;Jellin;Synamol;Synsac;Synandone;Localyn Syntex;Fluovitif;6α,9-Difluoro-11β,21-dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione;Sinalar;Radiocin;RS 1401AT;Synandrone;Percutina;Prodermin;Dermatin;Synaflan;Dermatin (steroid);Fluocinolone 16α,17α-acetonide;Fluzon;Synotic;Fluovitef;NSC 92339;Coriphate;Fluonid;Localyn;Synemol;Cortiplastol;Fluvean;Retisert;Sinaflan;Iluvien
CAS No.:67-73-2
Molecular Formula:C24H30F2O6
InChIKeys:InChIKey=FEBLZLNTKCEFIT-VSXGLTOVSA-N
Molecular Weight:452.49
Exact Mass:452.49
EC Number:200-668-5
UNII:0CD5FD6S2M
NSC Number:92339
DSSTox ID:DTXSID0040674
NCI Thesaurus Code:C29055
Color/Form:CRYSTALS FROM ACETONE & HEXANE|WHITE, CRYSTALLINE POWDER
ATC Code:C - Cardiovascular system|D - Dermatologicals|S - Sensory organs
HScode:2937210000
Categories:
Characteristics-
PSA:
93.1
XLogP3:2.48
Appearance:Solid
Density:1.4±0.1 g/cm3
Melting Point:266 °C
Boiling Point:578.5±50.0 °C at 760 mmHg
Flash Point:303.7±30.1 °C
Refractive Index:1.577
Water Solubility:soluble in water (partly), DMSO, alcohol, chloroform and methanol.
Storage Conditions:Refrigerator
Toxicity:LD50 oral in rat: > 4gm/kg
Specific rotation:D +95° (chloroform)
Odor:ODORLESS
PKA:13.9None
Dissociation Constants:13.9
Collision Cross Section:199.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:DECOMP IN HEAT
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
">Company Profile -
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
India
Fluocinolone Acetonide
0.25 G Dec 19, 2023 Post an enquiry for this product
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