tBuO-Ste-Glu(OtBu)-AEEA-AEEA-OSU 98% Yellowish liquid
1 Inquiries
1118767-15-9
98%
Main China
100g/bag
2022-09-28
SNAC,tBuO-Ste-Glu(AEEA-AEEA-OH)OtBu,Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH,Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH
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Product Description
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Seller Information
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Inquiry History
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DescriptionBasic Info
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Product Name:
(S)-21,39-di-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate
CAS No.:1118767-15-9
Categories:
Research-
Class:
GLP-1R agonist
Status:FDA-approved (Ozempic / Wegovy / Rybelsus)
Mechanism:Long-acting, selective glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. Engineered for extended half-life (~1 week) via albumin binding (fatty acid acylation at Lys26) and resistance to DPP-4 degradation (Aib substitution at position 8). Promotes insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces appetite via central nervous system GLP-1R activation.
Activity note:Potent, selective GLP-1R agonist. Reported binding affinity Ki = 0.38 ± 0.06 nM. Semaglutide is a human GLP-1 analog with structural modifications for albumin binding (C18 fatty diacid at Lys26) and enzymatic stability (Aib8 substitution).
Source:Lau J, et al. J Med Chem. 2015;58(18):7370-7380. Wilding JPH, et al. N Engl J Med. 2021;384(11):989-1002.DOI
Clinical Development:FDA:Ozempic, Wegovy, Rybelsus (approved 2017-12-05)
References-
ChEMBL:DrugBank:KEGG DRUG:PubChem:Literature:
NEJM: Wilding et al. (2021) — STEP-1; NEJM: Marso et al. (2016) — SUSTAIN-6; J Med Chem: Lau et al. (2015) — Discovery of Semaglutide; FDA: Ozempic (NDA 209637)
Disclaimer:Semaglutide is approved as a prescription medicine (Ozempic, Wegovy, Rybelsus) in certain jurisdictions. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.
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Seller Information
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Business Type:
Manufactory
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Main Products:
SNAC,tBuO-Ste-Glu(AEEA-AEEA-OH)OtBu,Fmoc-L-Lys[Oct-(otBu)-Glu-(otBu)-AEEA-AEEA]-OH,Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH
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Location:
Chengdu city, Sichuan China
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Payment Terms:
TT against copy of documents,D/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
200 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
101-200
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Year of Establishment:
2008
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Singapore
High quality 99% purity Semaglutide intermediate fast delivery
1 KG Jun 24, 2025 Post an enquiry for this product
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