SodiuM Aescinate 99%

Sodium aescinate (trade name: Maitongna) is a triterpene saponin sodium salt proposed in the dried and mature fruit of Borneo seed. It is extracted from the mature fruit of the crude drug horse chestnut abroad. Studies show that it can resist infection, exudation and swelling; Enhance the tension and contraction of blood vessel wall and improve microcirculation; Anti tumor and liver protection; Antioxidant, scavenging free radicals; Promote gastrointestinal peristalsis and inhibit gastric acid secretion; It has neuroprotective effect on ischemic brain tissue; Hypoglycemic effect. It is mainly used for the treatment of acute facial neuritis, headache, acute myelitis, neck, shoulder, waist and leg pain, hypertensive cerebral hemorrhage, acute cerebral infarction, central serous chorioretinopathy, early postoperative inflammatory intestinal obstruction, and pressure ulcers. This information is compiled by the Oriental editor of ChemicalBook. The dried mature fruit (Borneo) of Aesculus wilsonii, a plant of Aesculaceae, is the source plant. Fig. 1 shows the pharmacological effects of Borneo seed 1. Anti infection, anti exudation and detumescence: the action site is the blood vessel wall, and the permeability of the blood vessel wall increases during the inflammatory reaction. Sodium aescinat can change the permeability of the inflammatory capillaries, promote the re absorption of edema, prevent neutrophils from entering the microcirculation, keep the vascular endothelial cells non adherent to neutrophils, and prevent the adhesion, activation, exudation of neutrophils and secondary vein wall damage, Prevent the development of local inflammation. It has been proved that aescin can eliminate rat paw swelling induced by ovalbumin and dextran at the initial stage of inflammation. Oral administration of aescin can reduce rat capillary permeability induced by histamine and 5-hydroxytryptamine, and reduce rabbit capillary permeability induced by chloroform. The experimental study results of anti brain edema after hemorrhage showed that: in the treatment group, it was observed under the light microscope that the hemorrhage and cell edema after treatment were significantly reduced, the ultrastructure of mitochondria, endoplasmic reticulum and so on tended to be complete, and the biochemical test found that the concentration of Na+decreased significantly, and the concentration of K+increased significantly, which indicated that sodium aescinat had a significant therapeutic effect on brain edema after experimental cerebral hemorrhage. 2. Enhance the tension and contractility of blood vessel wall and improve microcirculation: it can promote the selective release of prostaglandin F-2 from vein α, Increase vein tension, promote lymphatic return, improve capillary blood stasis, and improve microcirculation. The application of sodium aescinate can significantly enhance the venous pressure and flow velocity of dog limbs and the chest lymph flow velocity. 3. Anti-tumor and liver protection: it can inhibit the proliferation of human chronic myeloid leukemia k562 cells. The tumor volume decreased gradually with the increase of drug dosage when mice were treated with liver cancer. It can reduce the increase of alanine aminotransferase caused by carbon tetrachloride induced liver injury in mice, and has obvious protective effect on experimental liver injury in mice. 4. Antioxidant free radical scavenging: it can significantly reduce the energy consumption of tissue cells and maintain the function of vascular endothelial cells. At the same time, sodium aescinate can effectively reduce the production of reactive oxygen species by activating endothelial cells, increasing the adhesion to neutrophils and reducing neutrophil exudation. Chemicalbook and sodium aescinate can reduce the consumption of superoxide dismutase, more effectively eliminate oxygen free radicals, improve the damage caused by bleeding, and accelerate tissue repair. 5. Promote gastrointestinal peristalsis and inhibit gastric acid secretion: its use has a significant inhibitory effect on the increase of gastric acid secretion caused by gastrin and histamine, and can participate in gastric acid regulation through neural and endocrine pathways. 6. Neuroprotective effect on ischemic brain tissue: The experimental rats blocked the left middle cerebral artery for reperfusion, and immediately intraperitoneal injection of sodium aescinat. The area of cerebral infarction in the treatment group was significantly smaller than that in the control group, and the number of apoptosis was significantly less than that in the control group. It has a protective effect on transient and local cerebral ischemia in rats. 7. Hypoglycemic effect: when sodium aescinate exists in the jejunum, it can reduce the absorption of glucose, achieve the goal of reducing glucose by inhibiting the absorption of glucose in the digestive tract, and has a preventive and therapeutic effect on diabetes caused by increased blood sugar after meals. Clinical application (1) Acute facial neuritis: Compared with prednisone, there was no statistically significant difference in the cure rate and improvement rate between the two groups in the treatment of idiopathic acute facial neuritis (P>0.05), but sodium aescinate prevented adverse reactions of corticosteroid hormones. (2) Headache: sodium aescinat combined with acetylglutamine has significant effects on the treatment of angioneurotic headache, premenstrual tension headache, and the treatment of headache caused by traumatic subarachnoid hemorrhage combined with mannitol. (3) Acute myelitis: The cure rate and improvement rate of acute myelitis treated with vitamin B, dibazol, acupuncture and sodium aescinat were significantly higher than those treated with corticosteroid. (4) Neck, shoulder, waist and leg pain: the cure rate and improvement rate of using it to treat lumbar disc herniation were significantly higher than using Yaotongning+chlorzoxazone; The total effective rate of sodium aescinate combined with mannitol in the treatment of cervical spondylotic radiculopathy was significantly higher than that of dexamethasone+mannitol. (5) Hypertensive intracerebral hemorrhage and acute cerebral infarction: sodium aescinate can significantly reduce intracranial pressure, accelerate the absorption of brain edema and hematoma, contribute to the recovery of neural function, and play the role of hormone like anti infection, anti exudation and detumescence by promoting the secretion of adrenal cortisol. (6) Central serous chorioretinopathy: sodium aescinate can improve the absorption of protein deposits and pigment deposits in the macular area, improve the vision after treatment, and the recurrence rate is low. (7) Early inflammatory intestinal obstruction after operation: it can promote the recanalization of intestinal obstruction and alleviate the pain of long-term catheter placement of patients, which is related to the effect of sodium aescinat on reducing intestinal wall edema and inflammatory exudation of the intestine and promoting intestinal peristalsis. (8) Pressure sore: its treatment of pressure sore can soften the induration, reduce exudation, and relieve pain. It has faster effect and shorter course of treatment than previous treatment methods. The chemical property is derived from the sodium saponin obtained from the extract of dried mature fruit (Sambucus orientalis) of the leafy tree plant Tianshi chestnut. Use: Used for content determination/identification/pharmacological experiment, etc. Pharmacological effect: It is used for brain edema, swelling caused by trauma or surgery, and also for venous reflux disorders. Purposes Sodium aescinate is a detumescence and anti-inflammatory drug. It has the effects of anti exudation, increasing vein tension, detumescence, anti inflammation and improving blood circulation.