475085-57-5, {4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid Huateng Pharma
475085-57-5
Huateng Pharma
upon inquiry
2022-11-02
fine chemicals,peg derivatives,pharma intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceProstacyclin (PGI2) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. MRE-269 is the active form of the prodrug NS-304. It is a potent and selective agonist for the human IP receptor with a Kivalue of 20 nM. In contrast to PGI2, which has a half-life of 30 seconds to a few minutesin vivo, plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs. Unlike the PGI2analogues, beraprost and iloprost, MRE-269 lacks high affinity for the EP3receptor. As a result, MRE-269 induces vasodilation equally in large and small pulmonary arteries, whereas vasodilation of small arteries by beraprost and iloprost is reducedviaEP3-mediated vasoconstriction.
ChEBI: A member of the class of pyrazines that is {4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetic acid carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. The active metabolite of selexipag, an orphan drug used for the treatm nt of pulmonary arterial hypertension.Basic Info-
Product Name:
[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
Other Name:[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID;MRE-269;ACT 333679;2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid;Selexipag Active Metabolite (ACT-333679);{4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid;MRE-269 (ACT-333679);MRE-269 Selexipag Active Metabolite
CAS No.:475085-57-5
Molecular Formula:C25H29N3O3
InChIKeys:OJQMKCBWYCWFPU-UHFFFAOYSA-N
Molecular Weight:419.52
Exact Mass:419.52
Color/Form:Off-White to Light Yellow
Categories:
Characteristics-
Density:
1.160
Melting Point:116 - 118°C
Boiling Point:602.1±55.0 °C(Predicted)
PKA:3.51±0.10(Predicted)
Critical Temperature & Pressure:Hygroscopic, -20°C Freezer, Under inert atmosphere
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
fine chemicals,peg derivatives,pharma intermediates
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Location:
Lugu Business Plaza E1,Yuelu District, Changsha City, Hunan Province
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Payment Terms:
TT against copy of documents
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Average lead Time:
30
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
301-500
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Year of Establishment:
2013
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
