475086-01-2, Selexipag Huateng Pharma
475086-01-2
Huateng Pharma
upon inquiry
2022-11-02
fine chemicals,peg derivatives,pharma intermediates
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceSelexipag and its active metabolite, the corresponding carboxylic acid, are nonprostanoid prostaglandin I2 (PGI-2) receptor agonists. The N-methylsulfonamide within selexipag is hydrolyzed to the corresponding carboxylic acid in vivo by hepatic microsomes at a rate which provides a slow-release pharmacological effect. The compound was originally discovered by Nippon Shinyaki and later licensed to Actelion for development. The drug was approved in 2015 and first launched for the oral treatment of pulmonary arterial hypertension (PAH) in the U.S. in 2016 to delay disease progression and reduce the risk of hospitalization.
ChEBI: Selexipag is a member of the class of pyrazines that is N-(methanesulfonyl)-2-{4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetamide carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. An orphan drug used for the treatment of pulmonary arterial hypertension. It is a prodrug for ACT-333679 (the free carboxylic acid). It has a role as an orphan drug, a prostacyclin receptor agonist, a platelet aggregation inhibitor, a vasodilator agent and a prodrug. It is a monocarboxylic acid amide, an ether, a member of pyrazines, an aromatic amine, a tertiary amino compound and a N-sulfonylcarboxamide. It is functionally related to an ACT-333679.Basic Info-
Product Name:
Selexipag
Other Name:Selexipag;ACT-293987;NS-304(Selexipag);Selexipag API;2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-ylaMino]butoxy]-N-MethylsulfonylacetaMide;AcetaMide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-Methylethyl)aMino]butoxy]-N- (Methylsulfonyl)-;Slipper;Selexipag intermediate 1
CAS No.:475086-01-2
Molecular Formula:C26H32N4O4S
InChIKeys:QXWZQTURMXZVHJ-UHFFFAOYSA-N
Molecular Weight:496.62
Exact Mass:496.62
Color/Form:Pale Yellow
Categories:
Characteristics-
Density:
1.210±0.06 g/cm3(Predicted)
Melting Point:134-138°C
PKA:3.82±0.40(Predicted)
Critical Temperature & Pressure:-20°C Freezer
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Seller Information
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Business Type:
Manufactory
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Main Products:
fine chemicals,peg derivatives,pharma intermediates
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Location:
Lugu Business Plaza E1,Yuelu District, Changsha City, Hunan Province
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Payment Terms:
TT against copy of documents
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Average lead Time:
30
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
301-500
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Year of Establishment:
2013
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
