Native Bovine Deoxyribonuclease I
9003-98-9
2026-10-07
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Native Bovine Deoxyribonuclease I Cat No NATE-0198 Description Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis. Abbr DNASE1, Native (Bovine) Alias DNASE1; DNase I Source Bovine pancreas Species Bovine Applications Used for the removal of DNA from protein samples. DNAse I is used to nick DNA as a first step to incorporate labeled bases into DNA. The enzyme from Creative Enzymes has been used in the processing of rat brain tissue. This study showed that axonal growth on astrocytes is not inhibited by oligodendrocytes. In another study, thawed fixed samples of E. coli were digested with DNAse I from Creative Enzymes along with other enzymes. The digestion was done before permeabilization and staining of the nucleic acids. Deoxyribonuclease I from bovine pancreas has been used in a study to investigate a two-dimensional zymogram analysis of nucleases in Bacillus subtilis. Deoxyribonuclease I from bovine pancreas has also been used in a study to investigate the effects of minor and major groove-binding drugs and intercalators on the DNA association of minor groove-binding proteins RecA and deoxyribonuclease I. Product Overview Protein determined by biuret. Form Lyophilized powder containing calcium chloride Enzyme Commission Number EC 3.1.21.1 Activity > 2,000 Kunitz units/mg protein; > 400 Kunitz units/mg protein; > 2,000 units/mg protein CAS No 9003-98-9 Molecular Weight mol wt ~31 kDa Unit Definition One Kunitz unit will produce a ΔA260 of 0.001 per min per mL at pH 5.0 at 25°C, using DNA, Type I or III as substrate. [Mg2+] = 4.2 mM. Storage −20°C Buffer 0.15 M NaCl: soluble 5.0 mg/mL, clear, colorless Function actin binding; deoxyribonuclease I activity; endodeoxyribonuclease activity Synonyms DNASE1; deoxyribonuclease I; deoxyribonuclease-1; DNase I; 9003-98-9; EC 3.1.21.1; pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease category Enzymes and Coenzymes Drugs(c1513) cas_num 9003-98-9 Basic Info-
Product Name:
Deoxyribonuclease
Other Name:Deoxyribonuclease;Nuclease,deoxyribo-;Dornase;Dornava;Dornavac;Pancreatic deoxyribonuclease;Pancreatic dornase;DNase;Deoxyribonucleic phosphatase;E.C. 3.1.4.5;DNAase;Deoxyribonuclease I;Alkaline deoxyribonuclease;Alkaline DNase;DNA nuclease;Desoxyribonuclease;DNase 1;DNA endonuclease;Deoxyribonuclease (pancreatic);Deoxyribonuclease A;Nuclease,Escherichia coli endo-,I;DNA depolymerase;Endodeoxyribonuclease I;E.C. 3.1.21.1;DNase B;NUC18 nuclease;Endonuclease S;DNase Y;DNase γ;Endonuclease DNAS1L3;Dnasel;Deoxyribonuclease 1;Endodeoxyribonuclease 1;DNA Degradase Plus;DNase I;Prepro-DNase;Nuclease,preprodeoxyribo-;NEBNext dsDNA Fragmentase;Deoxyribonucleases;DNases;Cryonase;Cryonase Cold Active Nuclease;Shearase;DNase A;9002-00-0;9036-35-5;9037-43-8;9037-64-3;9038-13-5;211926-10-2;1009555-43-4
CAS No.:9003-98-9
EC Number:232-667-0
HScode:35079090
Categories:
Characteristics-
Appearance:
white solution (clear, colorless)
Density:100 g/mL at 20 °C
Water Solubility:Soluble in 0.15 M sodium chloride (5.0mg/L) clear.
Storage Conditions:−20°C
Hazard IdentificationClassification of the substance or mixture
Respiratory sensitization, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P284 [In case of inadequate ventilation] wear respiratory protection.
Response P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product