Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName CB 1954 Cat No CSUB-0375 Form solid CAS No 21919-05-1 Storage -20°C Synonyms 5-(1-Aziridinyl)-2, 4-dinitrobenzamide; 5-(Aziridin-1-yl)-2, 4-dinitrobenzamide MDL Number MFCD00869490 PubChem Substance ID 24278301.0 Substrates NAD(P)H quinone oxidoreductase 2 category Specialty Chemicals(c26) cas_num 21919-05-1 ECHEMI Editorial ReferenceTretazicar (CB 1954), an antitumor prodrug, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1)[1][2].
Tretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).|Tretazicar is a prodrug of a bifunctional alkylating, dinitrobenzamide derivative with antineoplastic activity. Tretazicar can be activated by the human enzyme quinone oxidoreductase 2 (NQO2) in the presence of the cosubstrate caricotamide, an analogue of the natural cosubstrate dihydronicotinamide riboside (NRH), which acts as an electron donor. The resulting active, but short-lived metabolite, dinitrobenzamide, leads to DNA replication inhibition and the induction of apoptosis in NQO2 expressing cancer cells. Due to the lack of the natural cosubstrate NRH, NQO2 expression is normally latent but is upregulated in certain types of tumor cells.Research & Reference NoteCB 1954 is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Authoritative sourcesDisclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
Basic Info-
Product Name:
Tretazicar
Other Name:Benzamide,5-(1-aziridinyl)-2,4-dinitro-;5-(1-Aziridinyl)-2,4-dinitrobenzamide;2,4-Dinitro-5-ethyleneiminobenzamide;5-Aziridinyl-2,4-dinitrobenzamide;CB 1954;5-Aziridino-2,4-dinitrobenzamide;2,4-Dinitroethyleneiminobenzamide;NSC 115829;Tretazicar
CAS No.:21919-05-1
Molecular Formula:C9H8N4O5
InChIKeys:InChIKey=WOCXQMCIOTUMJV-UHFFFAOYSA-N
Molecular Weight:252.18
Exact Mass:252.18
EC Number:606-863-5
UNII:7865D5D01M
NSC Number:115829
DSSTox ID:DTXSID00176335
NCI Thesaurus Code:C81554
HScode:2933990090
Categories:
Characteristics-
PSA:
138
XLogP3:0
Density:1.7±0.1 g/cm3
Boiling Point:427.2°C at 760 mmHg
Flash Point:212.2±28.7 °C
Refractive Index:1.715
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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