WYE-354
1062169-56-5
99%
2026-08-08
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName WYE-354 Cat No CEI-0086 Description As a specific and ATP-competitive inhibitor, WYE-354 can potently inhibit mTOR with IC50 of 5 nM. CAS No 1062169-56-5 Molecular Weight 495.53 Purity >99% Storage 2 years at -20 centigrade Targets mTOR Molecular Formula C24H29N7O5 Solubility DSMO 99 mg/mL Water In vitro WYE-354 can inhibit mTOR, PI3K-alpha and PI3K-gamma with IC50 of 5 nM, 1.89 uM and 7.37 uM.In HEK293 cells, WYE-354 (0.2 uM-5 uM) effectively inhibits both mTORC1 and mTORC2. WYE-354 (0.3 uM-10 uM). The apoptosis induced by WYE-354 is accompanied by G1 cell cycle arrest and caspases activation. In vivo WYE-354 (50 mg/kg) effectively inhibits mTOR signaling and tumor growth in a mice xenograft model of PTEN-null PC3MM2 tumor. category Inhibitors(c1514) cas_num 1062169-56-5 Basic Info-
Product Name:
WYE-354
Other Name:WYE-354;4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;WYE-354 (Degrasyn);Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip
CAS No.:1062169-56-5
Molecular Formula:C24H29N7O5
InChIKeys:IMXHGCRIEAKIBU-UHFFFAOYSA-N
Molecular Weight:495.53096
Exact Mass:495.223022
EC Number:-0
DSSTox ID:DTXSID00657912
Categories:
Characteristics-
PSA:
124
XLogP3:1.9
Density:1.46
Flash Point:313.2±30.1 °C
Refractive Index:1.692
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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