AZD8055
1009298-09-2
99%
2026-07-24
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AZD8055 Cat No CEI-0118 Description AZD8055 can inhibit mTOR with IC50 of 0.8 nM. CAS No 1009298-09-2 Molecular Weight 465.54 Purity >99% Storage 2 years at -20centigrade Powder Targets mTOR Molecular Formula C25H31N5O4 Chemical Name (5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol Solubility DMSO 93 mg/mL Water 2 mg/mL Ethanol 15 mg/mL In vitro As a ATP-competitive inhibitor, AZD8055 can inihibit mTOR kinase with IC50 of 0.8 nM. AZD8055 shows inhibition to the phosphorylation of p70S6K and 4E-BP1, both of which are mTORC1 substrates. AZD8055 also can inhibit phosphorylation of the mTORC2 substrate AKT and downstream proteins. AZD8055 shows excellent selectivity (approximately 1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells.AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. In vivo In mice bearing U87-MG (PTEN null) glioblastoma xenografts, oral treatment with AZD8055 resulted in a dose-dependent tumor growth inhibition of 33%, 48%, and 77% with 2.5, 5, and 10 mg/kg/d twice daily, respectively. Antitumor activity in vivo induced by AZD8055 administered orally at a dose of 10 mg/kg twice daily or 20 mg/kg daily. category Inhibitors(c1514) cas_num 1009298-09-2 Basic Info-
Product Name:
5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Other Name:Benzenemethanol,5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-;5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol;[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-2-methoxyphenyl]methanol;[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol;AZD 8055;CCG 168;NVP-CCG 168;[5-[2,4-Bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol;AZD-8055;AZD8055
CAS No.:1009298-09-2
Molecular Formula:C25H31N5O4
InChIKeys:InChIKey=KVLFRAWTRWDEDF-IRXDYDNUSA-N
Molecular Weight:465.54474
Exact Mass:465.54
EC Number:-0
UNII:970JJ37FPW
HScode:29335990
Categories:
Characteristics-
PSA:
93.1
XLogP3:2.6
Density:1.248
Boiling Point:694.3±65.0 °C(Predicted)
Flash Point:373.7±34.3 °C
Refractive Index:1.609
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product