GDC-0941
957054-30-7
99%
Yes
2026-10-26
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName GDC-0941 Cat No CEI-0125 Description GDC-0941 can inhibit p110-alpha with IC50 of less than 10 nM. CAS No 957054-30-7 Molecular Weight 513.64 Purity >99% Storage 2 years at -20centigrade Powder Targets p110-alpha Molecular Formula C23H27N7O3S2 Chemical Name 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine Solubility DMSO 44 mg/mL Water In vitro GDC-0941, a class I selective PI3K inhibitor, can inhibit p110-alpha with IC50 of less than 10 nM. GDC-0941 showed a high efficacy of antitumor activity in two gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines, A549 and H460,as H460 cells with activating mutations of PIK3CA were relatively more sensitive to GDC-0941 than A549 cells with wild-type PIK3CA. In vivo In GIST xenograft models, GDC-0941 causes tumor growth stabilization, inhibiting tumor cell proliferation, but did not induce apoptosis. Combination of DOX with the specific PI3K inhibitor GDC-0941 can lead to caspase 3 activation in xenografts of sarcoma cells. category Inhibitors(c1514) cas_num 957054-30-7 ECHEMI Editorial ReferenceGDC-0941 (Pictilisib) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
Pictrelisib is a sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is a sulfonamide, a member of piperazines, a member of morpholines, a member of indazoles and a thienopyrimidine.|Pictilisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Advanced Solid Tumours, Metastatic Breast Cancer, and Non-Hodgkin's Lymphoma, Solid Cancers, among others.|Pictilisib is a small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.Basic Info-
Product Name:
Pictilisib
Other Name:Thieno[3,2-d]pyrimidine,2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-;2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine;4-[2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)piperazin-1-yl]methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine;GDC 0941;Pictilisib;GDC 941;GNE 0941;1146702-55-7
CAS No.:957054-30-7
Molecular Formula:C23H27N7O3S2
InChIKeys:InChIKey=LHNIIDJUOCFXAP-UHFFFAOYSA-N
Molecular Weight:513.64
Exact Mass:513.64
EC Number:1312995-182-4
UNII:ICY00EMP8P
DSSTox ID:DTXSID40241930
NCI Thesaurus Code:C165479
HScode:29350090
Categories:
Characteristics-
PSA:
144
XLogP3:1.6
Density:1.5±0.1 g/cm3
Flash Point:369.7±34.3 °C
Refractive Index:1.753
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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