XL147
956958-53-5
99%
2026-08-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName XL147 Cat No CEI-0132 Description XL 147 can inhibit p110-alpha with IC50 of 40 nM. Alias SAR245408 CAS No 956958-53-5 Molecular Weight 448.52 Purity >99% Storage 2 years at -20centigrade Powder Synonyms SAR245408 Targets p110-alpha Molecular Formula C21H16N6O2S2 Chemical Name N-(3-(benzo[c][1,2,5]thiadiazol-5-ylamino)quinoxalin-2-yl)-4-methylbenzenesulfonamide Solubility DMSO 89 mg/mL Water In vitro XL147, an ATP-competitive reversible PI3K inhibitor, exhibits an IC50 against WT and mutant p110 alpha of approximately 40 nM. Treatment with XL147 can inhibit the monolayer growth of all cell lines in a dose-dependent manner. The IC50 value is around 6 uM. At 20 uM, XL147 induced cell death as revealed by the reduction. In all cell lines, treatment with XL147 resulted in dose-dependent inhibition of PI3K as measured by pAKT(S473). Consistent with the inhibition of cell proliferation, XL147 induced a reduction in cyclin D1 and pRB and an increase in levels of the CDK inhibitor p27(KIP1). In vivo Addition of trastuzumab or lapatinib would enhance the antitumor effect of XL147 against HER2-dependent xenografts. category Inhibitors(c1514) cas_num 956958-53-5 Basic Info-
Product Name:
XL147
Other Name:N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide,;XL147;SAR245408;N-[3-(Benzo[c][1,2,5]thiadiazol-5-ylaMino)quinoxalin-2-yl]-4-MethylbenzenesulfonaMide;XL-147(SAR245408);PI3K inhibitorX;N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide XL 147;XL147 analogue
CAS No.:956958-53-5
Molecular Formula:C21H16N6O2S2
InChIKeys:MQMKRQLTIWPEDM-UHFFFAOYSA-N
Molecular Weight:448.52074
Exact Mass:448.07800
Categories:
Characteristics-
PSA:
149.61000
XLogP3:5.06300
Density:1.538
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product