LY2228820
862507-23-1
99%
2026-07-24
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName LY2228820 Cat No CEI-0171 Description LY2228820 can inhibit p38 MAPK with IC50 of 7 nM. CAS No 862507-23-1 Molecular Weight 612.74 Purity >99% Storage 2 years at -20centigrade Powder Targets p38 MAPK Molecular Formula C24H29FN6.2CH4O3S Chemical Name 5-(2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate Solubility DMSO 35 mg/mL Water 123 mg/mL Ethanol 3 mg/mL In vitro LY2228820 signi?cantly inhibited phosphorylation of HSP27, a downstream target of p38MAPK. LY2228820 alone does not inhibit the growth of MM cell lines, it synergistically enhanced cytotoxicity and apoptosis triggered by bortezomib. LY2228820 modulates the BM microenvironment of MM cells, inhibits in vitro osteoclastogenesis induced by M-CSF and sRANKL. In vivo LY2228820 blocks in vivo osteoclastogenesis in a SCID-hu MM model. category Inhibitors(c1514) cas_num 862507-23-1 Basic Info-
Product Name:
LY2228820
Other Name:LY2228820;5-[2-(1,1-DiMethylethyl)-5-(4-fluorophenyl)-1H-iMidazol-4-yl]-3-(2,2-diMethylpropyl)-3H-iMidazo[4,5-b]pyridin-2-aMine DiMethanesulfonate;LY2228820(LY-2228820);LY2228820 2MsOH;LY2228820 diMesylate;5-[2-(tert-Butyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine methanesulfonate;5-(2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate;5-(2-(tert-butyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate
CAS No.:862507-23-1
Molecular Formula:C26H37FN6O6S2
InChIKeys:NARMJPIBAXVUIE-UHFFFAOYSA-N
Molecular Weight:612.7369832
Exact Mass:612.219971
UNII:QUW7B71FO9
DSSTox ID:DTXSID60235457
NCI Thesaurus Code:C105853
Categories:
Characteristics-
PSA:
211
Boiling Point:634.4°C at 760 mmHg
Flash Point:337.5ºC
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product