VX-745
209410-46-8
99%
2026-08-23
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName VX-745 Cat No CEI-0172 Description VX-745 CAS No 209410-46-8 Molecular Weight 436.26 Purity >99% Storage 2 years -20centigrade Powder Targets p38-alpha MAPK, p38-beta MAPK Molecular Formula C19H9Cl2F2N3OS Solubility No In vitro VX-745,a lead anti-inflammatory candidate, is a small-molecule inhibitor of mitogen-activated protein kinase (MAPK). VX-745 inhibits interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) secretion in bone marrow stromal cells (BMSCs), without affecting their viability. VX-745 can also inhibit tumor necrosis factor alpha (TNF-alpha)-induced IL-6 secretion in BMSCs. VX-745 inhibits both MM cell proliferation and IL-6 secretion in BMSCs triggered by adherence of MM cells to BMSCs. VX-745 can inhibit paracrine MM cell growth in the BM milieu and overcome cell adhesion-related drug resistance. VX-745 potently inhibited TNF release from LPS stimulated human THP-1 cells with IC50s of 29 nM. category Inhibitors(c1514) cas_num 209410-46-8 Basic Info-
Product Name:
5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
Other Name:6H-Pyrimido[1,6-b]pyridazin-6-one,5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-;5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one;VX 745;Neflamapimod;VRT 031745;VD 31745
CAS No.:209410-46-8
Molecular Formula:C19H9Cl2F2N3OS
InChIKeys:InChIKey=VEPKQEUBKLEPRA-UHFFFAOYSA-N
Molecular Weight:436.26
Exact Mass:436.26
UNII:TYL52QM320
DSSTox ID:DTXSID90175115
HScode:2933990090
Categories:
Characteristics-
PSA:
70.3
XLogP3:5.1
Density:1.6±0.1 g/cm3
Melting Point:261-264 °C
Boiling Point:578.9ºC at 760mmHg
Flash Point:303.9±32.9 °C
Refractive Index:1.692
Storage Conditions:Store at -20°C
Vapor Pressure:2.13E-13mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product