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AT-406

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CAS No.:

1071992-99-8

Content:

99%

Price valid (until):

2026-08-10

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Description

ProductName	AT-406
Cat No	CEI-0179
Description	AT-406(SM-406) can inhibit XIAP, cIAP1, and cIAP2 proteins with Ki of 66.4, 1.9, and 5.1 nM.
CAS No	1071992-99-8
Molecular Weight	561.71
Purity	>99%
Storage	2 years at -20 centigrade
Targets	XIAP, cIAP1, cIAP2
Molecular Formula	C32H43N5O4
Chemical Name	(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxo-decahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
Solubility	DSMO 112 mg/mL Water
In vitro	AT-406(SM-406) is a novel, potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). AT-406(SM-406) can inhibit XIAP, cIAP1, and cIAP2 proteins with Ki of 66.4, 1.9, and 5.1 nM. AT-406(SM-406) can induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. In ovarian cancer cells, AT-406(SM-406) shows therapeutic efficacy and mechanism of action in 60% of human ovarian cancer cell lines. AT-406 induced apoptosis is correlated with its ability to down-regulate XIAP whereas AT-406 induces cIAP1 degradation in both AT-406 sensitive and resistance cell lines.
In vivo	In vivo, AT-406(SM-406) inhibits ovarian cancer progression and shows therapeutic potential for patients with inherent or acquired platinum resistance.In the combination with carboplatin, AT-406(SM-406) shows therapeutic efficacy.In vivo, AT-406(SM-406) enhances the carboplatin-induced ovarian cancer cell death and increases survival of the experimental mice by making ovarian cancer cells more sensitive to carboplatin.
category	Specialty Chemicals(c26)
cas_num	1071992-99-8

Basic Info

Product Name:

AT-406(AT406)

Other Name:

AT-406(AT406);(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(MethylaMino)propanaMido)-3-(3-Methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxaMide;SM 406;(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo[1,2-a][1,5]diazocine-8-carboxamide;AT-406 (SM-406);AT406 (SM-406, ARRY-334543);(5S,8S,10aR)-N-(Diphenylmethyl)decahydro-5-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-3-(3-methyl-1-oxobutyl)-6-oxopyrrolo[1,2-a][1,5]diazocine-8-carboxamideAT406 (SM-406, ARRY-334543);(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahyd

CAS No.:

1071992-99-8

Molecular Formula:

C32H43N5O4

InChIKeys:

LSXUTRRVVSPWDZ-MKKUMYSQSA-N

Molecular Weight:

561.71492

Exact Mass:

561.332

UNII:

N65WC8PXDD

DSSTox ID:

DTXSID50648496

NCI Thesaurus Code:

C90574

HScode:

29339900

Categories:

Characteristics

PSA:

111

XLogP3:

3.1

Density:

1.21

Boiling Point:

840.6±65.0 °C(Predicted)

See More AT-406(AT406) Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More AT-406(AT406) Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.
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AT-406

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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