Cyclopamine
1 Inquiries
4449-51-8
99%
2026-08-08
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Cyclopamine Cat No CEI-0202 Description Cyclopamine can inhibit Smoothened with IC50 of 46 nM. Alias 11-deoxojervine CAS No 4449-51-8 Molecular Weight 411.62 Purity >99% Storage 2 years at -20centigrade Powder Synonyms 11-deoxojervine Targets Smoothened Molecular Formula C27H41NO2 Chemical Name Spiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3a,4,4,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-octadecahydro-3,6,10,11b-tetramethyl-, (2R,3S,3R,3aS,6S,6aS,6bS,7aR,11aS,11bR)- Solubility DMSO In vitro Cyclopamine can inhibit Hedgehog (Hh) signaling pathway by inhibiting Smoothened (Smo) with IC50 of 46 nM. Cyclopamine inhibits Hedgehog signaling by directly binding to the heptahelical bundle of Smoothened (Smo). Besides binding to Smo, cyclopamine also can reverse the retention of partially misfolded Smo in the endoplasmic reticulum, presumably through binding-mediated effects on protein conformation. In vivo At low concentrations, combination of cyclopamine and gefitinib can inhibit the growth of EGF plus SHH-stimulated and serum-stimulated androgen-responsive LNCaP-C33 and androgen-independent LNCaP-C81, DU145, and PC3 cells. combination of cyclopamine and gefitinib also can cause a higher rate of apoptotic death of prostate cancer cells compared with individual agents. category Inhibitors(c1514) cas_num 4449-51-8 Basic Info-
Product Name:
Cyclopamine
Other Name:Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11,11a,11b-octadecahydro-3′,6′,10,11b-tetramethyl-,(2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-;Cyclopamine;Veratraman-3-ol,17,23-epoxy-,(3β,23β)-;Jervine,11-deoxo-;(2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-1,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11,11a,11b-Octadecahydro-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-3-ol;11-Deoxyjervine;11-Deoxojervine;(-)-Cyclopamine;11051-96-0;26108-61-2
CAS No.:4449-51-8
Molecular Formula:C27H41NO2
InChIKeys:InChIKey=QASFUMOKHFSJGL-LAFRSMQTSA-N
Molecular Weight:411.62
Exact Mass:411.62
UNII:ZH658AJ192
NSC Number:734950
DSSTox ID:DTXSID6043709
HScode:29349990
Categories:
Characteristics-
PSA:
41.5
XLogP3:5.33070
Appearance:solid
Density:1.1±0.1 g/cm3
Melting Point:224-227 °C
Boiling Point:550.794°C at 760 mmHg
Flash Point:286.9±30.1 °C
Refractive Index:1.583
Water Solubility:DMSO: soluble
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H341 Suspected of causing genetic defects
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
cyclopamine
500 MG Jan 28, 2025 Post an enquiry for this product