PP-121
1092788-83-4
99%
2026-08-03
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PP-121 Cat No CEI-0017 Description PP121 can inhibit a list of kinases including PDGFR, Hck, mTOR, VEGFR2, Src, bcr-Abl, p110alpha, DNA-PK, p110delta, EphB4, Src(T338I), EGFR, p110gamma, p110beta with IC50 of 2nM, 8nM, 10nM, 12nM, 14nM, 18nM, 52nM, 60nM, 150nM, 190nM, 220nM, 260nM, 110nM, 1400nM. CAS No 1092788-83-4 Molecular Weight 319.36 Purity >99% Storage 2 years at -20 centigrade Targets PDGFR, Hck, mTOR, VEGFR2, Src Molecular Formula C17H17N7 Chemical Name 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Solubility DSMO 64 mg/mL Water In vitro PP121 can inhibit a list of kinases including PDGFR, Hck, mTOR, VEGFR2, Src, bcr-Abl, p110alpha, DNA-PK, p110delta, EphB4, Src(T338I), EGFR, p110gamma, p110beta with IC50 of 2nM, 8nM, 10nM, 12nM, 14nM, 18nM, 52nM, 60nM, 150nM, 190nM, 220nM, 260nM, 110nM, 1400nM. Actually, PP121 can potently inhibit both tyrosine kinases and PI3-Ks but not serine-threonine kinases. And PP121 also shows inhibition to tube formation. Actually, PP121 potently blocked tube formation with IC50 of 0.31 nM. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in U87 and LN229, both of which are glioblastoma cell lines. Because of the PTEN feedback loop existing in U87, PP121 shows more potent inhibition to LN229 than U87. Actually, PP121 directly inhibit kinases such as PI3K and mTOR to block PI3K signaling pathway rather than inhibit upstream RTKs, so that PP121 shows little inhibition to ERK until 10 uM.PP121 potently inhibited the proliferation of a subset of these lines, and the inhibition of PP121 is as potent as that of PP103. PP121 induced a G0G1 arrest in most tumor cells. PP121 can override resistance in CML by inhibiting Abl, PI3K and mTOR at the same time. category Inhibitors(c1514) cas_num 1092788-83-4 Basic Info-
Product Name:
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Other Name:1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;PP 121;4-(Pyridin-3-yl) pyriMidin-2-aMineIMatinib;1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine PP 121;PTK/PI 3-K/mTOR Inhibitor, PP121
CAS No.:1092788-83-4
Molecular Formula:C17H17N7
InChIKeys:NVRXTLZYXZNATH-UHFFFAOYSA-N
Molecular Weight:319.36378
Exact Mass:319.154541
UNII:5B9VB06146
DSSTox ID:DTXSID00648002
Categories:
Characteristics-
PSA:
98.3
XLogP3:2.1
Appearance:off-white
Density:1.63
Boiling Point:650.889ºC at 760 mmHg
Flash Point:347.4±30.1 °C
Refractive Index:1.881
Water Solubility:DMSO: >10mg/mL
Storage Conditions:Store at +4°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product