AMG458
913376-83-7
99%
2026-06-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AMG458 Cat No CEI-0032 Description AMG458 CAS No 913376-83-7 Molecular Weight 539.58 Purity >99% Storage 2 years at -20 centigrade Targets human c-Met Molecular Formula C30H29N5O5 Solubility No In vitro AMG 458 can potently inhibit human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM. AMG-458 enhances radiosensitivity in H441 but not in A549. A549 expresses low levels of c-Met, which were phosphorylated only in the presence of exogenous hepatocyte growth factor. The combination of radiation therapy and AMG-458 treatment synergistically increase apoptosis in the H441 cell line but not in A549. Radiation therapy, AMG-458, and combination treatment were found to reduce p-Akt and p-Erk levels in H441 but not in A549. H441 became less sensitive to AMG-458 after small interfering RNA knockdown of c-Met; there was no change in A549. After overexpression of c-Met, A549 became more sensitive, while H441 became less sensitive to AMG-458. AMG-458 is more effective in cells that expressed higher levels of c-Met/p-Met. category Inhibitors(c1514) cas_num 913376-83-7 Basic Info-
Product Name:
AMG 458
Other Name:AMG 458;1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide;1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-
CAS No.:913376-83-7
Molecular Formula:C30H29N5O5
InChIKeys:GLBZSOQDAOLMGC-UHFFFAOYSA-N
Molecular Weight:539.58176
Exact Mass:539.216858
EC Number:-0
UNII:4535RW5Y3A
DSSTox ID:DTXSID80238521
Categories:
Characteristics-
PSA:
123.99000
XLogP3:3.02
Density:1.3±0.1 g/cm3
Refractive Index:1.672
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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