GSK1838705A
1116235-97-2
99%
2026-08-22
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName GSK1838705A Cat No CEI-0038 Description As a small-molecule kinase inhibitor, GSK1838705A can inhibit IGF-IR, the insulin receptor and ALK with IC50 of 2 nM, 1.6 nM and 0.5 nM. CAS No 1116235-97-2 Molecular Weight 532.57 Purity >99% Storage 2 years at -20 centigrade Targets IGF-IR, IR(Insulin receptor), ALK Molecular Formula C27H29FN8O3 Chemical Name 2-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluoro-N-methylbenzamide Solubility DSMO 107 mg/mL Water In vitro As a small-molecule kinase inhibitor, GSK1838705A can inhibit IGF-IR and the insulin receptor with IC50 of 2 nM and 1.6 nM. GSK1838705A also inhibits ALK (anaplastic lymphoma kinase), which drives the aberrant growth of anaplastic large-cell lymphomas, some neuroblastomas, and a subset of non-small cell lung cancers, with an IC50 of 0.5 nM. In vivo GSK1838705A blocks the in vitro proliferation of cell lines derived from solid and hematologic malignancies, including multiple myeloma and Ewings sarcoma, and retards the growth of human tumor xenografts in vivo. By inhibiting ALK, GSK1838705A can cause complete regression of ALK-dependent tumors. category Inhibitors(c1514) cas_num 1116235-97-2 Basic Info-
Product Name:
GSK1838705A
Other Name:GSK1838705;2-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-6-fluoro-N-methylbenzamide;2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamideGSK1838705A;2-[[2-[[1-[2-(Dimethylamino)acetyl]-2,3-dihydro-5-methoxy-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methy;GSK1838705A;2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide
CAS No.:1116235-97-2
Molecular Formula:C27H29FN8O3
InChIKeys:HZTYDQRUAWIZRE-UHFFFAOYSA-N
Molecular Weight:532.58
Exact Mass:532.235
Categories:
Characteristics-
PSA:
128
XLogP3:3.8
Appearance:white to light brown
Density:1.399
Water Solubility:DMSO: soluble20mg/mL, clear
Storage Conditions:-20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product