Vatalanib base
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CAS No.:
212141-54-3
Content:
99%
Price valid (until):
2026-07-21
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Vatalanib base Cat No CEI-0054 Description Vatalanib base can inhibit VEGFR-2 (KDR), VEGF-R1(FLT-1), Flk and c-Kit with IC50 of 37 nM, 77 nM, 270 nM and 730 nM. Alias ZK222584 CAS No 212141-54-3 Molecular Weight 346.81 Purity >99% Storage 2 years at -20centigrade Powder Synonyms ZK222584 Targets VEGFR-2 (KDR) Molecular Formula C20H15ClN4 Chemical Name N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride Solubility DMSO 85 mg/mL Water 10 mg/mL Ethanol 6 mg/mL In vitro Vatalanib base can inhibit VEGFR-2 (KDR), VEGF-R1(FLT-1), Flk and c-Kit with IC50 of 37 nM, 77 nM, 270 nM and 730 nM. Vatalanib base inhibits VEGF-induced autophosphorylation of kinase insert domain-containing receptor (KDR), endothelial cell proliferation, migration, and survival. Vatalanib base induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model, as well as a tumor cell-driven angiogenesis. In vivo (1) Renal cell carcinoma (RCC):As a specific inhibitor of both VEGF-receptor tyrosine kinases, Vatalanib base potently inhibits tumor growth, metastases formation, and tumor vascularization in murine renal cell carcinoma. (2) MM cell lines: Vatalanib base acts both directly on MM cells and in the bone marrow microenvironment. Specifically, Vatalanib base (1-5 micro M) inhibits proliferation of MM cells by 50%. This effect of vatalanib base is dose dependent in both MM cell lines. Vatalanib base enhances the inhibitory effect of dexamethasone on growth of MM cells and can overcome the protective effect of interleukin 6 (IL-6) against dexamethasone-induced apoptosis. Vatalanib base (1 micro M) also blocks VEGF-induced migration of MM cells across an extracellular matrix. Importantly, Vatalanib base also inhibits the increased MM cell proliferation and increased IL-6 and VEGF secretion in cultures of MM cells adherent to bone marrow stem cells. (3) Malignant glioma cell lines:Early and delayed application of Vatalanib base in V(+) glioma-bearing animals resulted in a significant reduction of tumor size (71% and 36%, P (4) Models of rheumatoid arthritis:Vatalanib base treatment caused dose dependent reduction in the vascularity of the granulomatous air pouch model. Vatalanib base inhibited knee swelling by 40% in antigen-induced arthritis. category Specialty Chemicals(c26) cas_num 212141-54-3 Basic Info-
Product Name:
Vatalanib
Other Name:1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-;N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine;CGP 79787;Vatalanib;Pynasunate;Vatalinib
CAS No.:212141-54-3
Molecular Formula:C20H15ClN4
InChIKeys:InChIKey=YCOYDOIWSSHVCK-UHFFFAOYSA-N
Molecular Weight:346.81
Exact Mass:346.81
UNII:5DX9U76296
DSSTox ID:DTXSID2046919
NCI Thesaurus Code:C1868
Categories:
Characteristics-
PSA:
50.7 Ų
Density:1.330±0.06 g/cm3
Melting Point:209-212 °C
Boiling Point:587.8±50.0 °C(Predicted)
PKA:5.46±0.10
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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