Tivozanib(AV-951)
475108-18-0
99%
Yes
2026-11-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
Tivozanib (CAS No.: 475108-18-0) is supplied by Creative Enzymes, a Manufactory with 6 years on ECHEMI.
Key details: content 99%.
Sample is available.
Contact the supplier on this page to request a quotation or the latest price.
ECHEMI Editorial ReferenceTivozanib (AV-951; KRN951) is a highly potent and selective VEGFR 1/2/3 inhibitor with IC50s of 0.21, 0.16, and 0.24 nM in cell assay, respectively.
1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea is an aromatic ether.|Tivozanib has been used in trials studying the treatment and basic science of Solid Tumors, Glioblastoma, Ovarian Cancer, Prostate Cancer, and Stage IV Disease, among others.|Tivozanib is a Kinase Inhibitor. The mechanism of action of tivozanib is as a Tyrosine Kinase Inhibitor.|Tivozanib is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.Basic Info-
Product Name:
Tivozanib
Other Name:Urea,N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)-;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)urea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N′-(5-methyl-3-isoxazolyl)urea;KRN 951;AV 951;Tivozanib;Kil 8951;1-[2-Chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;Fotivda
CAS No.:475108-18-0
Molecular Formula:C22H19ClN4O5
InChIKeys:InChIKey=SPMVMDHWKHCIDT-UHFFFAOYSA-N
Molecular Weight:454.86
Exact Mass:454.86
UNII:172030934T
NCI Thesaurus Code:C85444
ATC Code:L01EK03|L - Antineoplastic and immunomodulating agents
Categories:
Characteristics-
PSA:
108
XLogP3:4
Density:1.4±0.1 g/cm3
Boiling Point:550.4±50.0°C at 760 mmHg
Flash Point:286.7±30.1 °C
Refractive Index:1.680
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15 days
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product
- Hot Searches
- bioglutide peptide for sale
- specialty chemical emulsifier supplier
- sr 17018 buy online cheap
- alpha olefin sulfonate price
- current market price for propane
- n-isopropylbenzylamine for sale
- bioglutide for sale
- enterobacter cloacae
- etoricoxid
- succinic acid
- doperidon
- polypropylene price per ton in nigeria 2026
