KX2-391
897016-82-9
99%
2026-07-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName KX2-391 Cat No CEI-0263 Description KX2-391 can inhibit Src with IC50 of 72 nM. CAS No 897016-82-9 Molecular Weight 431.53 Purity >99% Storage 2 years at -20 centigrade Targets Src Molecular Formula C26H29N3O3 Chemical Name N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide Solubility DSMO 86 mg/mL Water In vitro As a small molecule and non-ATP competitive inhibitor, KX2-391 can inhibit Src tyrosine kinase signaling inhibitor with an IC50 of 72 nM by targeting the substrate binding pocket of Src. KX2-391 can also inhibit tubulin polymerization. For cell lines KX2-391 can inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. In vivo In pre-clinical animal models of cancer, orally administered KX2-391 was shown to inhibit primary tumor growth and to suppress metastasis. In combination with certain chemotherapeutic agents, KX2-391 can reduce the doses of some current cytotoxic agents. KX2-391 is currently in Phase-2 testing for solid tumors. category Inhibitors(c1514) cas_num 897016-82-9 Basic Info-
Product Name:
KX2-391
Other Name:KX 01;5-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide;N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide
CAS No.:897016-82-9
Molecular Formula:C26H29N3O3
InChIKeys:HUNGUWOZPQBXGX-UHFFFAOYSA-N
Molecular Weight:431.52676
Exact Mass:431.220886
UNII:4V9848RS5G
DSSTox ID:DTXSID30237862
NCI Thesaurus Code:C74077
ATC Code:D06BX03|D - Dermatologicals
Categories:
Characteristics-
PSA:
63.7
XLogP3:2.9
Density:1.2±0.1 g/cm3
Boiling Point:680.859ºC at 760 mmHg
Flash Point:365.6±31.5 °C
Refractive Index:1.588
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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