R406
841290-81-1
99%
2026-06-30
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName R406 Cat No CEI-0269 Description R406 can inhibit syk with IC50 of 30 nM. CAS No 841290-81-1 Molecular Weight 628.63 Purity >99% Storage 2 years at -20centigrade Powder Targets syk Molecular Formula C22H23FN6O5.C6H6O3S Chemical Name 6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one benzenesulfonate Solubility DMSO 126 mg/mL Water In vitro As an ATP-competitive inhibitor, R406 can inhibit spleen tyrosine kinase (Syk) with Ki of 30nM. R406 inhibit spleen tyrosine kinase (Syk), which plays a key role in the signaling of activating Fc receptors and the B-cell receptor (BCR), by bounding to the ATP binding pocket of Syk. R406 inhibited phosphorylation of Syk substrate linker for activation of T cells in mast cells and B-cell linker protein/SLP65 in B cells. R406 can block Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 was selective as assessed using a large panel of Syk-independent cell-based assays representing both specific and general signaling pathways.R406 can also potently inhibit immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling with EC50 of 56-64 nM. In vivo R406 can block Syk, which is the key component of BCR signaling. And antigenic stimulation through the B-cell antigen receptor (BCR) is considered to promote the expansion of chronic lymphocytic leukemia (CLL) B cells. Researchers confirmed that R406 inhibited constitutive and BCR-induced activation of Syk, extracellular signal-regulated kinases, and AKT, and blocked BCR-induced calcium mobilization and blocked these BCR-dependent responses in CLL cells. Immunotoxicity Syk signaling plays critical roles in regulating the lymphohematopoietic system, but inhibition of Syk by R406 leads to minimal functional immunotoxicity notwithstanding its lymphocytopenic effect. Inhibition of Syk might not lead to unacceptable mechanism-based adverse effects. category Inhibitors(c1514) cas_num 841290-81-1 Basic Info-
Product Name:
R406
Other Name:6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one benzenesulfonate;R406(benzenesulfonate);6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one benzenesulfonate;R406, >=98%;R406 tosilate;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2
CAS No.:841290-81-1
Molecular Formula:C28H29FN6O8S
InChIKeys:UXDRJPYSTZHIOE-UHFFFAOYSA-N
Molecular Weight:628.6286632
Exact Mass:628.175171
Categories:
Characteristics-
PSA:
192
XLogP3:5.22730
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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