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PCI-32765(Ibrutinib)

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CAS No.:

936563-96-1

Content:

99%

Price valid (until):

2026-07-08

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
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Inquiry History

Description

ProductName	PCI-32765(Ibrutinib)
Cat No	CEI-0270
Description	PCI-32765(Ibrutinib) can inhibit bruton tyrosine kinase (Btk) with IC50 of 0.46 nM.
CAS No	936563-96-1
Molecular Weight	440.5
Purity	>99%
Storage	2 years at -20centigrade Powder
Targets	Bruton tyrosine kinase (Btk)
Molecular Formula	C25H24N6O2
Chemical Name	(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
Solubility	DMSO 88 mg/mL Water
In vitro	As a selective and irreversible Btk inhibitor, PCI-32765 can inhibit Bruton tyrosine kinase (Btk) with IC50 of 0.46 nM. As Bruton tyrosine kinase (Btk) is specifically required for BCR signaling, PCI-32765 can block BCR signaling pathway by inhibiting Bruton tyrosine kinase (Btk). In CD40 or BCR activated CLL cells, PCI-32765 can inhibit BTK tyrosine phosphorylation and also effectively abrogates downstream survival pathways activated by this kinase including ERK1/2, PI3K, and NF-kappaB. In vitro, PCI-32765 inhibited BCR-activated primary B cell proliferation with IC50 of 8 nM. PCI-32765 blocked BCR signaling in human peripheral B cells at concentrations that did not affect T cell receptor signaling. As B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL), PCI-32765 inhibits activation-induced proliferation of CLL cells by inhibiting BTK, and effectively blocks survival signals provided externally to CLL cells from the microenvironment including soluble factors (CD40L, BAFF, IL-6, IL-4, and TNF-alpha), fibronectin engagement, and stromal cell contact.
In vivo	In MRL-Fas(lpr) lupus model, PCI-32765 reduced the level of circulating autoantibodies and completely suppressed disease. PCI-32765 also inhibited autoantibody production and the development of kidney disease in the MRL-Fas(lpr) lupus model.
category	Bulk Drug Intermediates(c1112)
cas_num	936563-96-1

Basic Info

Product Name:

Ibrutinib

Other Name:

2-Propen-1-one,1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one;PCI 32765;PCI 32765-00;CRA 032765;Ibrutinib;JNJ 02;Imbruvica;(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one;1881245-94-8

CAS No.:

936563-96-1

Molecular Formula:

C25H24N6O2

InChIKeys:

InChIKey=XYFPWWZEPKGCCK-GOSISDBHSA-N

Molecular Weight:

440.5

Exact Mass:

440.50

EC Number:

1308068-626-2

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

99.2

XLogP3:

3.6

Density:

1.34

Melting Point:

149-158ºC

Boiling Point:

715.0±60.0°C at 760 mmHg

Flash Point:

386.2±32.9 °C

Refractive Index:

1.696

Water Solubility:

Freely soluble in dimethyl sulfoxide; soluble in methanol

Storage Conditions:

Conditions for safe storage, including any incompatibilities: Keep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition. Recommended storage temperature: Store at -20 deg C.

Vapor Pressure:

3.97X10-15 mm Hg at 25 deg C (est)

PKA:

3.74None

See More Ibrutinib Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Ibrutinib Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Ibrutinib 99% white powder 936563-96-1 wholesale	1 MT	Sep 19, 2023
Qatar	Ibrutinib 99% white powder 936563-96-1 Lingding961	100 KG	Jul 25, 2023

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