Mitoxantrone HCl
70476-82-3
99%
Yes
2026-11-26
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Seller Information
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Description
ProductName Mitoxantrone HCl Cat No CEI-0277 Description Mitoxantrone HCl is a DNA-reactive agent and can inhibit topoisomerase II. Alias Novantrone CAS No 70476-82-3 Molecular Weight 517.4 Purity >99% Storage 2 years at -20 centigrade Synonyms Novantrone Targets Topoisomerase II Molecular Formula C22H30Cl2N4O6 Chemical Name 1,4-dihydroxy-5,8-bis(2-(2-hydroxyethylamino)ethylamino)anthracene-9,10-dione dihydrochloride Solubility DSMO 89 mg/mL Water 89 mg/mL Ethanol In vitro Mitoxantrone HCl is a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone HCl also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II. category Antineoplastic Agents(c1417) cas_num 70476-82-3 ECHEMI Editorial ReferenceMitoxantrone dihydrochloride is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
Mitoxantrone dihydrochloride is a hydrochloride. It has a role as an antineoplastic agent. It contains a mitoxantrone.|Mitoxantrone is an antineoplastic antibiotic that is used in the treatment of acute leukemia, lymphoma, and prostate and breast cancer, but also for late stage, severe multiple sclerosis. Mitoxantrone therapy is often accompanied by mild to moderate elevations in serum aminotransferase levels, but in typical doses it rarely causes clinically apparent, acute liver injury.|Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.|An anthracenedione-derived antineoplastic agent.Basic Info-
Product Name:
Mitoxantrone hydrochloride
Other Name:9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-,hydrochloride (1:2);9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-,dihydrochloride;CL 232315;Mitoxantrone hydrochloride;NSC 301739;DHAD;Novantrone;Mitoxantrone dihydrochloride;Bisantrone;Novatrone;Immunex;NCI 301739;Novantron;Mitoxantrone HCl;PW 3405
CAS No.:70476-82-3
Molecular Formula:C22H28N4O6.2ClH
InChIKeys:InChIKey=ZAHQPTJLOCWVPG-UHFFFAOYSA-N
Molecular Weight:517.4
Exact Mass:516.154236
EC Number:274-619-1
UNII:U6USW86RD0
DSSTox ID:DTXSID0045173
NCI Thesaurus Code:C665
Color/Form:Blue-black solid from water ethanol
HScode:2914610000
Categories:
Characteristics-
PSA:
163
XLogP3:2.39260
Melting Point:5-203 °C
Boiling Point:805.7ºC at 760 mmHg
Flash Point:441.1ºC
Water Solubility:soluble to 5 mM in water and to 75 mM in DMSO;Methanol < 1 (mg/mL)
Storage Conditions:Intact vials of the dark blue concentrate should be stored at room temp & protected from freezing. Refrigeration of the concentrate may cause a precipitate, which redissolves upon warming to room temp.
Collision Cross Section:195.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Hydroscopic
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 1B
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H340 May cause genetic defects
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Intact vials of the dark blue concentrate should be stored at room temp & protected from freezing. Refrigeration of the concentrate may cause a precipitate, which redissolves upon warming to room temp.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
