PHA-767491
845714-00-3
99%
2026-07-27
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName PHA-767491 Cat No CEI-0286 Description PHA-767491 CAS No 845714-00-3 Molecular Weight 213.24 Purity >99% Storage 2 years at -20 centigrade Targets Cdc7 Molecular Formula C12H11N3O Solubility No In vitro PHA-767491 is a potent Cdc7 inhibitor. PHA-767491 is the first molecule that directly affects the mechanisms controlling initiation as opposed to elongation in DNA replication. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. PHA-767491 prevents the activation of replication origins but does not impede replication fork progression, and it does not trigger a sustained DNA damage response. PHA-767491 induced apoptosis in all CLL samples tested with an average EC50 of 0.6 uM. PHA-767491 activates the intrinsic apoptotic pathway in resting CLL cells. Exposure of CLL cells to 1 uM PHA-767491 induced Bax activation occurs upstream of caspase activation. PHA-767491 induces downregulation of Mcl-1 protein in a caspase-independent manner. And DNA synthesis and Cdc7 activity of IL-4 and CD154-stimulated CLL cells can be inhibited by PHA-767491. category Inhibitors(c1514) cas_num 845714-00-3 Basic Info-
Product Name:
PHA 767491 HYDROCHLORIDE
Other Name:PHA 767491 HYDROCHLORIDE;1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-onehydrochloride;PHA-767491;CAY10572;1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one;2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one;PHA-767491HCL;PHA-767491 (CAY10572)
CAS No.:845714-00-3
Molecular Formula:C12H11N3O.ClH
InChIKeys:DKXHSOUZPMHNIZ-UHFFFAOYSA-N
Molecular Weight:249.7
Exact Mass:213.09
HScode:2933990090
Categories:
Characteristics-
PSA:
57.78000
XLogP3:2.49340
Density:1.287
Boiling Point:620.6ºC at 760 mmHg
Flash Point:329.1ºC
Storage Conditions:Desiccate at RT
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product