Flavopiridol HCl
146426-40-6
99%
2026-06-24
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Flavopiridol HCl Cat No CEI-0294 Description Flavopiridol (Alvocidib) can inhibit CDK1, CDK2, CDK4, CDK5, CDK6, and CDK9 with IC50 of CAS No 146426-40-6 Molecular Weight 401.84 Purity >99% Storage 2 years at -20centigrade Powder Targets CDK1/CDK2, CDK4/CDK5/CDK6, CDK9 Molecular Formula C21H20ClNO5 Chemical Name 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride Solubility DMSO 88 mg/mL Water 37 mg/mL Ethanol In vitro Flavopiridol (L86-8275), which is a potent cyclin-dependent kinase (CDK) inhibitor, can inhibit cell cycle progression in either G1 or G2. In vitro, flavopiridol can inhibit CDK2 with IC50 of 300 nM. Similarly, flavopiridol inhibited CDK4-cyclin D1 in vitro. As an ATP competitive inhibitor, flavopiridol can recombinant CDK4-cyclin D1 with Ki value of 65 nM. Flavopiridol inactivated positive transcription elongation factor b (P-TEFb), a kinase that phosphorylates and activates RNA poly-merase II (RNAP II), through the inhibition of CDK7 and CDK9. This inactivation resulted in decreased phosphorylation and transcriptional activity of RNAP II. Inhibition of P-TEFb led to decreased RNAP II activity, decreased gene transcription, down-modulation of a variety of antiapoptotic proteins such as Mcl-1,and induction of apoptosis. Flavopiridol can inhibit cell proliferation of MDA-MB-468 by inducing cell cycle arrest both in G1 and G2. category Specialty Chemicals(c26) cas_num 146426-40-6 Basic Info-
Product Name:
Alvocidib
Other Name:4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-;4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-,cis-(-)-;2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one;L 86-8275;Flavopiridol;HMR 1275;Alvocidib;(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-1-benzopyran-4-one;HL 275;L 868275;DSP 2033;358739-39-6
CAS No.:146426-40-6
Molecular Formula:C21H20ClNO5
InChIKeys:InChIKey=BIIVYFLTOXDAOV-YVEFUNNKSA-N
Molecular Weight:401.84
Exact Mass:401.84
UNII:45AD6X575G
DSSTox ID:DTXSID6048961
NCI Thesaurus Code:C74940
Categories:
Characteristics-
PSA:
94.14000
XLogP3:1.92
Appearance:Yellow powder
Density:1.448±0.06 g/cm3(Predicted)
Melting Point:52.5 °C
Boiling Point:603.6±55.0 °C(Predicted)
Flash Point:318.8±31.5 °C
Refractive Index:1.673
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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