BIBR 1532
321674-73-1
99%
2026-07-23
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName BIBR 1532 Cat No CEI-0304 Description BIBR 1532 can inhibit telomerase with IC50 of 93 nM. CAS No 321674-73-1 Molecular Weight 331.36 Purity >99% Storage 2 years at -20centigrade Powder Targets telomerase Molecular Formula C21H17NO3 Chemical Name (E)-2-(3-(naphthalen-2-yl)but-2-enamido)benzoic acid Solubility DMSO 66 mg/mL Water In vitro BIBR 1532 is a non peptidic, non nucleosidic small molecule capable of inhibiting the catalytic activity of telomerase. This synthetic antitelomerase compound interferes with the in vitro processivity of telomerase in a dose-dependent manner with half maximal inhibitory concentrations (IC50) of 93 nM.Telomerase inhibition using BIBR 1532 in human cancer cells from fibrosarcoma, prostate, breast, and lung carcinoma lead to progressive shortening of telomeres down to a critical checkpoint followed by triggering a DNA damage response. High doses of BIBR 1532 induce caspase 3 activity. BIBR 1532 inhibits telomerase activity in a dose-dependent manner. BIBR 1532 disturbs transcriptional balanced ratio between Bcl-2 and Bax in favor of apoptosis. BIBR 1532 can also downregulates c-Myc and hTERT expression and induce p21 mRNA overexpression. category Inhibitors(c1514) cas_num 321674-73-1 Basic Info-
Product Name:
BIBR 1532
Other Name:Benzoic acid,2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-;Benzoic acid,2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-butenyl]amino]-;2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-buten-1-yl]amino]benzoic acid;BIBR 1532
CAS No.:321674-73-1
Molecular Formula:C21H17NO3
InChIKeys:InChIKey=PGFQXGLPJUCTOI-WYMLVPIESA-N
Molecular Weight:331.37
Exact Mass:331.36
DSSTox ID:DTXSID70432975
Categories:
Characteristics-
PSA:
66.4
XLogP3:5.1
Density:1.3±0.1 g/cm3
Boiling Point:600.607°C at 760 mmHg
Flash Point:317.0±29.6 °C
Refractive Index:1.698
Storage Conditions:Store at RT
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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