PHA-848125
802539-81-7
99%
2026-08-16
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PHA-848125 Cat No CEI-0307 Description PHA-848125 can inhibit cyclin A/CDK2, cyclin H/CDK7,cyclin D1/CDK4,p35/CDK5, and cyclin E/CDK2 with IC50 of 45 nM, 150 nM, 160 nM, 265 nM and 363 nM. CAS No 802539-81-7 Molecular Weight 460.57 Purity >99% Storage 2 years at -20centigrade Powder Targets cyclin A/CDK2, cyclin H/CDK7, cyclin D1/CDK4, p35/CDK5, cyclin E/CDK2 Molecular Formula C25H32N8O Chemical Name N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide Solubility DMSO In vitro PHA-848125 is a potent dual inhibitor of CDKs and TRKs, possesses significant antitumor activity. PHA-848125 can inhibit cell proliferation of a wide panel of tumoral cell lines with submicromolar IC(50). PHA-848125-treated cells show cell cycle arrest in G(1) and reduced DNA synthesis, accompanied by inhibition of pRb phosphorylation and modulation of other CDK-dependent marker In vivo Following oral administration, PHA-848125 has significant antitumor activity in various human xenografts and carcinogen-induced tumors as well as in disseminated primary leukemia models, with plasma concentrations in rodents in the same range as those found active in inhibiting cancer cell proliferation. category Inhibitors(c1514) cas_num 802539-81-7 Basic Info-
Product Name:
PHA-848125
Other Name:PHA-848125;4,5-Dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide;Milciclib;PHA-848125 (Milciclib);Milciclib (PHA-848125);N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide;4,5-Dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide PHA 848125;4,5-Dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-pyrazolo[4,3-h]
CAS No.:802539-81-7
Molecular Formula:C25H32N8O
InChIKeys:RXZMYLDMFYNEIM-UHFFFAOYSA-N
Molecular Weight:460.59
Exact Mass:460.269897
EC Number:-0
UNII:688000M8S8
DSSTox ID:DTXSID80230186
NCI Thesaurus Code:C148410
Categories:
Characteristics-
PSA:
91.2
XLogP3:2.8
Density:1.3±0.1 g/cm3
Melting Point:190 °C
Refractive Index:1.692
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product