A-966492
934162-61-5
99%
2026-07-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName A-966492 Cat No CEI-0324 Description As a novel inhibitor, A-966492 can potently inhibit PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, CAS No 934162-61-5 Molecular Weight 324.35 Purity >99% Storage 2 years at -20 centigrade Targets PARP1 Molecular Formula C18H17FN4O Chemical Name 2-(2-fluoro-4-((S)-pyrrolidin-2-yl)phenyl)-3H-benzo[d]imidazole-4-carboxamide Solubility DSMO 65 mg/mL Water In vitro A-966492 is one of the most potent PARP inhibitors. A-966492 displays excellent potency against the PARP-1 enzyme with a Kiof 1 nM. In vivo A-966492 shows good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX-1 breast cancer xenograft model both as a single agent and in combination with carboplatin. In vivo, A-966492 demonstrates significant enhancement of the efficacy of TMZ in a murine B16F10 syngeneic melanoma model, with the A-966492 combination groups showing superior efficacy. category Inhibitors(c1514) cas_num 934162-61-5 Basic Info-
Product Name:
A-966492
Other Name:A-966492;2-[2-Fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide;A-966492(A 966492);2-{2-fluoro-4-[(2S)-pyrrolidin-2-yl]phenyl}-1H-1,3-benzodiazole-7-carboxaMide;2-[2-Fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamideA-966492;A-966492, >=98%
CAS No.:934162-61-5
Molecular Formula:C18H17FN4O
InChIKeys:AHIVQGOUBLVTCB-AWEZNQCLSA-N
Molecular Weight:324.36
Exact Mass:324.138641
DSSTox ID:DTXSID50586581
Categories:
Characteristics-
PSA:
83.8
XLogP3:0.96
Density:1.3±0.1 g/cm3
Boiling Point:605.5±65.0 °C at 760 mmHg
Flash Point:320.0±34.3 °C
Refractive Index:1.665
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product