Borrelidin
7184-60-3
99%
2026-06-26
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Borrelidin Cat No CEI-0401 Description A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC50 = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Also acts as a CDK inhibitor. Alias Treponemycin; U 78548; C2989 Appearance White to off-white solid Product Overview An angiogenesis inhibitor CAS No 7184-60-3 Molecular Weight 274.18 Purity >99% Storage -20 centigrade Synonyms Treponemycin; U 78548; C2989 Targets Angiogenesis Molecular Formula C 28 H 43 NO 6 Solubility DMSO (~ 5 mg/ml) Shipping Conditions Gel pack category Antibiotics(c1416) cas_num 7184-60-3 Basic Info-
Product Name:
Borrelidin
Other Name:Cyclopentanecarboxylic acid,2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]-,(1R,2R)-;Cyclopentanecarboxylic acid,2-(7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-,[2S-[2R*(1S*,2S*),4E,6Z,8S*,9R*,11S*,13R*,15R*,16R*]]-;Borrelidin;Oxacyclooctadecane,cyclopentanecarboxylic acid deriv.;(1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid;Borrelidine;Treponemycin;NSC 216128;(-)-Borrelidin;B 3061;Borrelidin A;97328-74-0;1403-11-8
CAS No.:7184-60-3
Molecular Formula:C28H43NO6
InChIKeys:InChIKey=OJCKRNPLOZHAOU-UGKRXNSESA-N
Molecular Weight:489.64
Exact Mass:489.64
HScode:29419090
Categories:
Characteristics-
PSA:
127.85000
XLogP3:4.31
Density:1.1±0.1 g/cm3
Melting Point:93-95 °C
Boiling Point:710.3±60.0 °C at 760 mmHg
Flash Point:383.4±32.9 °C
Refractive Index:1.539
Water Solubility:DMSO: 1 mg/mL
Storage Conditions:−20°C
Toxicity:Subcutaneous-rat LD50: 1.780 mg/kg; subcutaneous-mouse LD50: 75 mg/kg
Flammability characteristics:Thermal decomposition to emit toxic nitrogen oxide fumes
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product