Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Tenovin-1 Cat No CEI-0893 Description Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. CAS No 380315-80-0 Molecular Weight 369.48 Storage 2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO. Targets p53 Molecular Formula C20H23N3O2S Chemical Name Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)- Solubility DMSO 74 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL In vitro Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family. In vivo Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts. category Inhibitors(c1514) cas_num 380315-80-0 Basic Info-
Product Name:
TENOVIN-1
Other Name:TENOVIN-1;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide;Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin 1;Tenovin 1N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;Tenovin-1, >=98%
CAS No.:380315-80-0
Molecular Formula:C20H23N3O2S
InChIKeys:WOWJIWFCOPZFGV-UHFFFAOYSA-N
Molecular Weight:369.487
Exact Mass:369.151093
UNII:BIQ6AID2B7
DSSTox ID:DTXSID1046920
HScode:29242990
Categories:
Characteristics-
PSA:
102
XLogP3:4.4
Density:1.238±0.06 g/cm3 (20 ºC 760 Torr)
Refractive Index:1.651
Water Solubility:H2O: Insuluble (4.8E-3 g/L) (25 ºC)
Storage Conditions:Store at +4°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product