Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Entacapone Cat No CEI-1327 Product Overview Entacapone is a second-generation catechol-O-methyltransferase (COMT) inhibitor that potently inhibits rat liver total COMT with the half maximal inhibition concentration IC50 and inhibition constant Ki values of 20.1 nM and 10.7 nM respectively. The IC50 values of entacapone against rate liver soluble COMT (S-COMT) and rat liver membrane-bound COMT (MB-COMT) are 14.3 nM and 73.3 nM respectively. Entacapone has succbe used as an adjunct to standard levodopa-dopa decarboxylase inhibitor therapy in patients with Parkinson's disease (PD), for its abilities to increase the bioavailability of levodopa by inhibiting the generation of 3-O-methyldopa and to prolong the duration and clinical benefit of levodopa. CAS No 130929-57-6 Molecular Weight 305.29 Storage Store at -20°C Targets COMT Molecular Formula C14H15N3O5 Chemical Name (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Nervous System Drugs(c1422) cas_num 130929-57-6 Basic Info-
Product Name:
Entacapone
Other Name:2-Propenamide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-,(2E)-;2-Propenamide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-,(E)-;(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide;Entacapone;Comtan;OR 611;(E)-Entacapone;Entacom;Parkicapone;Comtess;116314-67-1
CAS No.:130929-57-6
Molecular Formula:C14H15N3O5
InChIKeys:InChIKey=JRURYQJSLYLRLN-BJMVGYQFSA-N
Molecular Weight:305.29
Exact Mass:305.29
UNII:4975G9NM6T
DSSTox ID:DTXSID5046439
NCI Thesaurus Code:C61746
Color/Form:Crystals from acetic acid + hydrochloric acid
ATC Code:N04BX02|N04BA03|N - Nervous system
HScode:2942000000
Categories:
Characteristics-
PSA:
130
XLogP3:2.1
Appearance:Solid
Density:1.4±0.1 g/cm3
Melting Point:162-163 °C
Boiling Point:526.6°C at 760 mmHg
Flash Point:272.3±30.1 °C
Refractive Index:1.642
Water Solubility:DMSO: soluble 20mg/mL, clear
Storage Conditions:-20°C Freezer
Vapor Pressure:3.25 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 6.76X10-19 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 5.95 (primary phenol); pKa2 = 10.41 (secondary phenol) (est)|pKa approximately 4.5
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product