Laropiprant
571170-77-9
0.98%
2026-07-05
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Laropiprant Cat No CEI-1389 Product Overview Laropiprant (Cardaptive; MK 0524) is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively. Laropiprant (Cardaptive; MK 0524) inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia. CAS No 571170-77-9 Molecular Weight 435.9 Purity 0.98 Storage Store at -20°C Synonyms Cardaptive; MK 0524; MK-0524,Laropiprant Targets DP1 receptor Molecular Formula C21H19ClFNO4S Chemical Name 2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 571170-77-9 Basic Info-
Product Name:
Laropiprant
Other Name:Cyclopent[b]indole-3-acetic acid,4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-,(3R)-;(3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid;MK 0524;Laropiprant;Cardaptive;(R)-2-(4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid;895565-43-2
CAS No.:571170-77-9
Molecular Formula:C21H19ClFNO4S
InChIKeys:InChIKey=NXFFJDQHYLNEJK-CYBMUJFWSA-N
Molecular Weight:435.89600
Exact Mass:435.90
UNII:G7N11T8O78
DSSTox ID:DTXSID60205756
NCI Thesaurus Code:C87372
ATC Code:C10AD52
Categories:
Characteristics-
PSA:
84.75000
XLogP3:5.47090
Appearance:White to off-white solid
Density:1.486g/cm3
Melting Point:175 °C
Boiling Point:71014ºC
Flash Point:383.203ºC
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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