NVP-LCQ195
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CAS No.:
902156-99-4
Content:
0.98%
Price valid (until):
2026-08-10
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName NVP-LCQ195 Cat No CEI-1449 Product Overview NVP-LCQ195 is a pan-inhibitor of CDKs. Cyclin-dependent kinases (CDKs) are a family of protein kinases and play an important role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. In vitro kinase activity assays, NVP-LCQ195 blocks the activity of CDK1/cyclin B and CDK2/cyclin A, CDK2/cyclin E, as well as CDK5 (both CDK5 p25 and CDK5 p35) with IC50 value of 2 nM, 2 nM, 5 nM and 1 nM, respectively. Also, it inhibited CLK3 and CHEK2 (CHK2), CDK3/cyclin E, CDK9/cyclin T1, CDK7/cyclin H and CDK6/cyclin D3.In MM. 1S cells, NVP-LCQ195 (2 μM) increased the percentage of cells in S and G2/M phases early, followed by an increase in sub-G1 population. Also, NVP-LCQ195 suppressed the expression of transcription factors including myc, IRF4 and XBP-1.In bortezomib-treated MM patients, NVP-LCQ195 suppressed high expression of genes and significantly increased progression-free and overall survival. CAS No 902156-99-4 Molecular Weight 460.33 Purity 0.98 Storage Store at -20°C Synonyms LCQ-195; AT-9311; NVP LCQ195; LCQ 195; AT9311; AT 9311 Targets CDK1/CDK2/CDK5 Molecular Formula C17H19Cl2N5O4S Chemical Name 4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 902156-99-4 Basic Info-
Product Name:
Nvp-lcq195
Other Name:NVP-LCQ195;902156-99-4;4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide;LCQ-195;C17H19Cl2N5O4S;SCHEMBL2029686;SCHEMBL17252164;DTXSID90470112;3942AH;ZINC43131434
CAS No.:902156-99-4
Molecular Formula:C17H19Cl2N5O4S
InChIKeys:CCUXEBOOTMDSAM-UHFFFAOYSA-N
Molecular Weight:460.3
Exact Mass:459.0534807
DSSTox ID:DTXSID90470112
Categories:
Characteristics -
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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