PI-103 Hydrochloride
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CAS No.:
371935-79-4
Content:
0.98%
Sample Available:
Yes
Price valid (until):
2026-11-19
Company Type:
Manufactory
Location:
United States
Payment Terms:
TT against copy of documents,D/P
Average Lead Time:
15 days
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PI-103 Hydrochloride Cat No CEI-1479 Product Overview PI-103 is a dual inhibitor of PI3K/Akt and mTOR with IC50 value of 0.002 μM, 0.003μM, 0.003μM, 0.015μM, 0.030μM for P110α, P110β, P110γ, P110 and mTOR, respectively. PI3K/AKT/mTOR pathway is an intracellular signaling pathway and plays an important role in regulating cell cycle. It has been shown that PI3K/AKT/MTOR pathway is directly related to cellular quiescence, proliferation, cancer, and longevity. And many studies have shown that activation of the PI3K/Akt signaling pathway is correlated with poor prognosis in a variety of cancers which demonstrated that inhibition of the pathway may be regarded as a promising therapy. PI-103 is a selective PI3K/Akt and mTORC1 inhibitor. When tested with leukemic cell lines (MOLM14, OCI-AML3 and MV4-11) with activation of PI3K/Akt, mTORC1and ERK/MAPK signaling pathways, PI-103 blocked cells proliferation via inhibiting PI3K/Akt and mTORC1 activity in a concentration of 1μM. In HCC cell line--Huh7 cells, treated PI-103 alone or combined with sorafenib inhibited cells proliferation in a dose-dependent manner through inhibition of PI3K/Akt and mTORC1 pathways. When tested with U87MG glioblastoma cells, PI-103 treatment in 30 nM/L showed significant inhibition of PI3K/Akt and mTORC1 phosphorylation. In neuroblastoma cell lines SK-N-BE (2), IMR-32 with amplified MYCN, PI-103 inhibited cell growth in a time-and concentration-dependent manner via inhibiting PI3K/Akt and mTORC1 activity. In SK-N-BE (2) with MYCN-mutant xenografted nude mice model, treated PI-103 intraperitoneally (10 mg/kg) markedly reduced the tumor volume index and tumor weight via inhibiting PI3K/ mTOR pathways. CAS No 371935-79-4 Molecular Weight 384.82 Purity 0.98 Storage Store at -20°C Synonyms PI 103 hydrochloride; PI103 hydrochloride Targets DNA-PK/PI 3-kinase/mTOR Molecular Formula C19H17ClN4O3 Chemical Name 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol; hydrochloride Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 371935-79-4 Basic Info-
Product Name:
PI-103 (Hydrochloride)
Other Name:PI 103 HYDROCHLORIDE;PI103 HYDROCHLORIDE;PI-103, Hydrochloride Salt, >99%;3-[4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol monohydrochloride;PI103 Free base;PI-103 HCl;3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol,hydrochloride
CAS No.:371935-79-4
Molecular Formula:C19H17ClN4O3
InChIKeys:XSQMYBFFYPTMFE-UHFFFAOYSA-N
Molecular Weight:384.81628
Exact Mass:384.0989181
EC Number:604-604-1
DSSTox ID:DTXSID30587490
Color/Form:Light yellow to yellow
Categories:
Characteristics-
Critical Temperature & Pressure:
Store at -20°C
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Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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