PSI-6130
817204-33-4
0.98%
2026-07-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PSI-6130 Cat No CEI-1487 Description PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase Product Overview PSI-6130 is a selective and effective inhibitor of hepatitis C virus (HCV) RNA replication with an EC50 of 0.46 μM. It is a potent nucleoside analog which incorporates into nascent RNA by the HCV NS5B polymerase and leads to chain termination. NS5B is a viral protein discovered in hepatitis c virus. It plays a significant role in the replication of HCV, which uses HCV'S viral positive RNA strand as the template and catalyzes the polymerization of rNTP during RNA replication. PSI-6130 is a nucleotide analog and it can be activated by converting into nucleotide triphosphate form, which can be an alternative substrate in the synthesis of viral RNA. As a result PSI-6130 reduces the efficacy of further elongation of HCV RNA by NS5B. Studies reported PSI-6130 HCV replication inhibition effects. PSI-6130 activity of HCV replication was determined in Huh7 cells with a subgenomic genotype 1b Con1 strain. And the mean IC50 was 0.6 μM. And another study showed that PSI-6130 inhibited HCV GT-1b (Con1 strain) and GT-1a (H77 strain) subgenomic RNA replication, with similar levels of potency, whose mean EC 50 values are 0.51 and 0.30 μM, respectively. PSI-6130 could be transformed into two active metabolites, RO2433 and PSI-6026 respectively, in human primary hepatocytes by enzymes. Moreover, PSI-6130 showed little or no cytotoxicity against different cells, including human peripheral blood mononuclear and human bone marrow progenitor cells. Assessments of PSI-6130's activity against other viruses in the Flaviviridae family were conducted, which illustrated that PSI-6130 was not active against viruses including BVDV, WNV, YFV, HBV, and HIV. The results also showed that PSI-6130 is a selective HCV inhibitor. CAS No 817204-33-4 Molecular Weight 259.23 Purity 0.98 Storage Store at -20°C Synonyms R 1656; PSI 6130; PSI6130; R-1656 Targets Hepatitis C Virus Nucleoside Molecular Formula C10H14FN3O4 Chemical Name 4-amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Saccharides(c1518) cas_num 817204-33-4 Basic Info-
Product Name:
2′-Deoxy-2′-fluoro-2′-C-methylcytidine
Other Name:Cytidine,2′-deoxy-2′-fluoro-2′-methyl-,(2′R)-;(2′R)-2′-Deoxy-2′-fluoro-2′-methylcytidine;PSI 6130;R 1656;2′-Deoxy-2′-fluoro-2′-C-methylcytidine;2′-Deoxy-2′-fluoro-2′-C-methylcytidine;1001913-07-0
CAS No.:817204-33-4
Molecular Formula:C10H14FN3O4
InChIKeys:InChIKey=NYPIRLYMDJMKGW-VPCXQMTMSA-N
Molecular Weight:259.2342632
Exact Mass:259.23
UNII:05J68784G1
DSSTox ID:DTXSID10231287
Categories:
Characteristics-
PSA:
108
XLogP3:-0.72
Appearance:Pale brown solid
Density:1.7±0.1 g/cm3
Melting Point:216.4-218.0 °C @ Solvent: Ethanol
Boiling Point:482.4±55.0 °C at 760 mmHg
Flash Point:245.5±31.5 °C
Refractive Index:1.653
Storage Conditions:4ºC
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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