RG2833
1215493-56-3
0.98%
2026-06-24
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName RG2833 Cat No CEI-1502 Description RG2833 is a brain-penetrant inhibitor of HDAC with IC50 values of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. Product Overview RG2833 is a histone deacetylase (HDAC) inhibitor. In the neuronal cell, RG2833 increased Friedreich Ataxia (FXN) mRNA and protein levels, with concomitant changes in the epigenetic state of the gene. In PBMCs, RG2833 inhibited HDAC expression and increased H3K9 acetylation, and increased FXN mRNA in blood from patients. In iPSC-derived neuronal cell model, plasma RG2833 (5μM) inhibited maximal deacetylase and upregulated FXN. The result showed a good correlation between increase in FXN transcript and inhibition of deacetylase activity, providing evidence that the mechanism of action of RG2833 is through deacetylation. CAS No 1215493-56-3 Molecular Weight 339.43 Purity 0.98 Storage Store at -20°C Synonyms RG 2833; RG-2833; RGFP-109; RGFP109; RGFP 109 Targets HDAC1; HDAC3 IC50 60 nM; 50 nM Molecular Formula C20H25N3O2 Chemical Name N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Inhibitors(c1514) cas_num 1215493-56-3 Basic Info-
Product Name:
RGFP 109
Other Name:RG 2833;RG2833;RG-2833;RGFP 109;RGFP109;RGFP-109;N-[6-(2-Aminophenylamino)-6-oxohexyl]-4-methylbenzamide;RGFP 109 N-[6-(2-Aminophenylamino)-6-oxohexyl]-4-methylbenzamide
CAS No.:1215493-56-3
Molecular Formula:C20H25N3O2
InChIKeys:VOPDXHFYDJAYNS-UHFFFAOYSA-N
Molecular Weight:339.4314
Exact Mass:339.195
UNII:17V14R89EU
DSSTox ID:DTXSID20153300
Categories:
Characteristics-
PSA:
84.2
XLogP3:2.8
Density:1.163±0.06 g/cm3(Predicted)
Boiling Point:620.1±50.0 °C(Predicted)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product