Talarozole
2 Inquiries
201410-53-9
0.98%
Yes
2026-11-28
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Seller Information
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Inquiry History
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Description
ProductName Talarozole Cat No CEI-1547 Description Talarozole is a potent and selective inhibitor of cytochrome P450. Product Overview Talarozole is a selective inhibitor of cytochrome P450 with an IC50 at 4 nM. Cytochrome P450 is concerned with oxidative metabolism of many organic chemicals of diverse structure,both in exogenous and endogenous environment. Cytochrome P450 are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans-retinoic acid for the treatment of psoriasis and acne. Talarozole treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose, meanwhile, compared with vehicle-treated skin, decreased the expression of KRT2 and IL-1α. There was no mRNA change in retinol-metabolizing enzymes. No induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis substantiated an upregulation of KRT4 protein, however, there were no upregulation of CYP26B1 and CYP26A1 expression was found. There were 0.1% of the dose found in the skin itself after 12-24 h. The results of distribution of talarozole within the skin show that 80% was located in the epidermis, meanwhile, the remaining 20% was detected in the dermis. CAS No 201410-53-9 Molecular Weight 377.51 Purity 0.98 Storage Store at -20°C Synonyms Rambazole; R115866; R-115866; R 115866 Targets Cytochrome P450 Molecular Formula C21H23N5S Chemical Name N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 201410-53-9 ECHEMI Editorial ReferenceChEBI: N-{4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine is a member of the class of benzothiazoles that is 2-amino-1,3-benzothiazole in which one of the amino hydrogens is replaced by a 4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl group. It is a member of triazoles, a member of benzothiazoles, an aromatic amine and a secondary amino compound.Basic Info-
Product Name:
R 115866
Other Name:R 115866;RaMbazole;N-[4-[2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazolamine;N-(4-(2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine);RAMBAZOLE;R115866;R-115866;R 115866;N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine;Retinoid X receptors,R 115866,Retinoic acid receptors,RAR/RXR,inhibit,Talarozole,Cytochrome P450,CYPs,Inhibitor,Autophagy,R-115866;Talarozole, 10 mM in DMSO
CAS No.:201410-53-9
Molecular Formula:C21H23N5S
InChIKeys:SNFYYXUGUBUECJ-UHFFFAOYSA-N
Molecular Weight:377.51
Exact Mass:377.51
Color/Form:White to off-white
Categories:
Characteristics-
Density:
1.26±0.1 g/cm3(Predicted)
Boiling Point:561.0±60.0 °C(Predicted)
PKA:2.70±0.10(Predicted)
Critical Temperature & Pressure:Keep in dark place,Sealed in dry,Store in freezer, under -20°C
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
United States
Talarozole
1 MT Feb 4, 2026
United States
Talarozole
500 MG Feb 2, 2026 Post an enquiry for this product
