VX-702
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CAS No.:
479543-46-9
Content:
0.98%
Sample Available:
Yes
Price valid (until):
2026-11-21
Company Type:
Manufactory
Location:
United States
Payment Terms:
TT against copy of documents,D/P
Average Lead Time:
15 days
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Description
ProductName VX-702 Cat No CEI-1578 Description VX-702 is a highly selective inhibitor of p38α MAPK, Product Overview VX-702 is a selective inhibitor of p38α MAPK with IC50 value ranges from 4 nM to 20 nM. P38 mitogen-activated protein kinases (p38 MAPK), also named as MAPK14, are a class of mitogen-activated protein kinases and play an important role in a signaling cascade controlling cellular responses to cytokines and stress. VX-702 is a potent p38α MAPK inhibitor and is designed as for greater affinity and greater selectivity compared with the first reported p38α MAPK inhibitors. When tested with PLTs (platelets), VX-702 caused better maintenance of PLT mitochondrial, functional, structural and metabolic parameters during 7 days storage and restored PLTs properties following an extended interruption of agitation to levels of continuously agitated PLTs. In the isolated perfused rat kidney (IPRK) model, administration of VX-702 at a range of doses between 100 and 600 ng/mL showed linear excretion and the clearance data were consistent with net reabsorption by the kidney. Further, VX-702 was showed not a substrate for renal organic anion and organic cation transport systems. CAS No 479543-46-9 Molecular Weight 404.33 Purity 0.98 Storage Store at-20°C Targets p38α IC50 4 nM-20 nM Molecular Formula C19H12F4N4O2 Chemical Name 6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)pyridine-3-carboxamide Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 479543-46-9 Basic Info-
Product Name:
VX-702
CAS No.:479543-46-9
Categories:
-
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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