Biggest manufacturer of Polydatin
ISO FDA
65914-17-2
Pharmaceutical Grade
99%
shanghai
25kg
Yes
2023-08-31
chemicals,low price LCZ696 Intermediate,NICOTINAMIDE RIBOSIDE，NR,,4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine,Romidepsin (FK228, Depsipeptide),Alpha-GPC
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Product Description
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Seller Information
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DescriptionECHEMI Editorial Reference(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].
Polydatin (PD) is a major chemical component of Polygonum cuspidatum and it could also be found in a variety of other sources. PD is a polyphenol belonging to the chemical family of stilbenoids. Previous studies have shown that PD exhibits many pharmacological activities, including cardioprotective, neuroprotective, and antioxidative activities. With vascular dementia (VaD) rat models, PD markedly attenuated cognitive deficits. Biochemical analysis revealed that PD decreased the production of malondialdehyde (MDA) and significantly increased superoxide dismutase and catalase activities. Additionally, PD effectively alleviated the injuries of cultured neurons induced by oxygen–glucose deprivation. The therapeutic potential of PD for VaD seems related to its antioxidative activity and the direct protection of neurons. Furthermore, PD could also effectively inhibit the polymerization of amyloid-β peptides, which is a major mark in the progression of pathogenesis in Alzheimer’s disease (AD). These results suggest that PD is a promising drug candidate or nutraceutical for the treatment of VaD and AD.
3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside is a stilbene glucoside that has been found inV. viniferaand has diverse biological activities. It reduces the growth of SKOV3 ovarian cancer cell 3D aggregates in a concentration-dependent manner. 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (10 and 20 μg/ml) inhibits IL-17 production in activated peripheral blood mononuclear cells (PBMCs). It inhibits the loss of glutathione peroxidase 4 (GPX4) activity induced by the ferroptosis inducer hemin in Neuro2a neuroblastoma cells. 3,4′-5-Trihydroxystilbene-3-β-D-glucopyranoside (50 mg/kg) reduces escape latency in a rat model of vascular dementia induced by four-vessel occlusion (4-VO).
ChEBI: Trans-piceid is a stilbenoid that is trans-resveratrol substituted at position 3 by a beta-D-glucosyl residue. It has a role as a metabolite, a potassium channel modulator, an anti-arrhythmia drug, a hepatoprotective agent, an antioxidant, a nephroprotective agent and a geroprotector. It is a stilbenoid, a polyphenol, a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a trans-resveratrol.CertificatesBasic Info-
Product Name:
Polydatin
Other Name:3,4',5-TRIHYDROXYSTILBENE-3-BETA-MONOGLUCOSIDE;3,4'-5-TRIHYDROXYSTILBENE-3-BETA-D-GLUCOPYRANOSIDE;TRANS-RESVERATROL 3-O-BETA-D-GLUCURONIDE;TRANS-RESVERATROL-O-BETA-GLUCOSIDE;3,4'-5-TRIHYDROXYSTILBEENE-3-BETA-D-GLU&;Polydatine;3,4'-5-trihydroxystilbene-3-β-d-glucopyranoside;3,4',5-Trihydroxystilbene-3-b-D-glucopyranoside
CAS No.:65914-17-2
Molecular Formula:C20H22O8
InChIKeys:KRZZBNXOOOHROO-ONKCTLKBNA-N
Molecular Weight:390.38
Exact Mass:407.13400
BRN:54837
EC Number:200-001-8
Color/Form:White to off-white solid.
HScode:29389090
Categories:
Characteristics-
PSA:
140
XLogP3:1.7
Appearance:Solid
Density:1.521±0.06 g/cm3(Predicted)
Melting Point:223-226 °C(lit.)
Boiling Point:707.7±60.0 °C(Predicted)
Flash Point:381.8ºC
Specific rotation:-55 º (c=1,acetone)
PKA:9.31±0.10(Predicted)
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Serious eye damage, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H315 Causes skin irritation
H318 Causes serious eye damage
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
chemicals,low price LCZ696 Intermediate,NICOTINAMIDE RIBOSIDE，NR,,4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine,Romidepsin (FK228, Depsipeptide),Alpha-GPC
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Location:
No 7 ,Huacai International Building,Dengcai Road,Sandun,Westlake District,Hangzhou,Zhejiang
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Payment Terms:
L/C,100% TT in advance
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Average lead Time:
30 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
101-200
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Year of Establishment:
2011
Company Certificates-
ISO
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FDA
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CE
Gihi Chemicals: is specialized in the production of ester products which are used in the daily dietary supplements chemicals ,cosmetic products and skincare products since 1999.
Since 2010，GIHI CHEMICALS , begun to focus on the development and production of high-quality healthy Dietary supplements for our global high-reputation customers. The purity of all healthy Dietary supplements we provide has reached more than 99% purity. From the beginning of our products’ development, our technical engineers have chosen and design the production routes to ensure that we have been able to use biological, enzyme and water-phase green synthesis methods during the large production process to ensure that our health dietary supplements is truly high-quality ,green &environmental friendly, which are truly good and health to the human body.
Now our company has:
1 sales & management center + 3 research centers+ 4 production factories.
with ISO9001 & FDA certificate & CE certificate, accordance with GMP requirements.
1 Sales &Management center:
Add:No.567 Dengcai Street, Sandun, Westlake District, Hangzhou 310030, Zhejiang, China.
Research Center 1: (Chemical synthesis lab)
No.6, Chanyexietongchuanxing Center, Kangyang Road, Shangyu Economic and Technological Development Zone, Shaoxing, Zhejiang，China.
This research center: is specialized in chemical synthesis, our this research center could synthesis more than 300 new chemical products for many china pharmaceutical companies every year.
Research Center 2:(For Enzyme biology technical and Enzyme catalyst technical)
No.7, Lixiangxi Road, changsha Economic and Technological Development Zone, Changsha, Hunan.
Our this research center is committed to the applications of immobilized enzymes technology to the development of products such as peptides, polysaccharides, and non-natural amino acids. The products developed are widely used in medicine, health products, cosmetics, food, feed and other industries. The company adopts multidisciplinary technologies of chemistry, materials science and life sciences, which helps to meet the demand of green production while improving product quality and economic benefits. And also helps to reduces the emission of "three industrial pollution" greatly.
Research Center 3:(Biology enzyme-catalytic products)
No.2 Bio-hatch Building,No.10 Gaoxinzhongyidao, Yuehai Street,Nanshan District, Shenzhen, Guangdong, China.
This research center is specialized in biosynthesis technology as the core technology, and multi-disciplinary cross-application as target. We are the first batch company in the world to apply enzyme catalysis technology to the large-scale production of peptides, carbohydrates and nucleic acids and other special functional raw materials, and actively explore products in new application in the field. In this center, we used enzyme catalyst production methods to produce many high lever products, such as: NMN, (S)-Prox-ylane, Ectoin, Ergothioneine,etc.
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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